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In vitro discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom.
(2022)
The monocled cobra (Naja kaouthia) is among the most feared snakes in Southeast Asia due to its toxicity, which is predominantly derived from long-chain α-neurotoxins. The only specific treatment for snakebite envenoming ...
Pros and cons of different therapeutic antibody formats for recombinant antivenom development
(2018-05)
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many
advances in immunology, synthetic biology, and antibody research, different approaches and antibody
formats are being ...
Pros and cons of different therapeutic antibody formats for recombinant antivenom development
(2018-05)
Antibody technologies are being increasingly applied in the field of toxinology. Fuelled by the many
advances in immunology, synthetic biology, and antibody research, different approaches and antibody
formats are being ...
Serological investigation of rabies virus neutralizing antibodies in bats captured in the eastern Brazilian Amazon
(Oxford University Press, 2013-11-01)
Background: In 2004 and 2005 a total of 38 cases of human rabies transmitted by the hematophagous bat Desmodus rotundus were registered in the Brazilian state of Para;23 (60.5%) cases occurred in the northeastern region. ...
Human recombinant fab fragment neutralizes shiga toxin type 2 cytotoxic effects in vitro and in vivo
(MDPI, 2018-12)
Shiga toxin (Stx) producing Escherichia coli (STEC) is responsible for causing hemolytic uremic syndrome (HUS), a life-threatening thrombotic microangiopathy characterized by thrombocytopenia, hemolytic anemia, and acute ...
HIV-1 binding and neutralizing antibodies of injecting drug users
(Brazilian Journal of Medical and Biological Research, 2005)
Previous studies have demonstrated a stronger seroreactivity against some synthetic peptides responsible for inducing neutralizing antibodies in injecting drug observed for plasma from the S group (15/23) than from the ...
Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and
leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide
efficient blockade for viral infection and are ...
Detection and quantification of anti-rabies glycoprotein antibodies: current state and perspectives
(Springer, 2021-09)
Rabies is an ancient fatal disease with no other available treatment than post-exposure vaccination, where the bite of infected animals, mainly dogs, is the leading cause of its transmission to human beings. In this context, ...
Molecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2
An elegant paper by Yuan et al., recently published in Science,
provides novel insights into the molecular features of neutralizing
antibody responses to the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2 ...