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Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines
(Landes Bioscience, 2011-12-01)
Epigenetic mechanisms are frequently deregulated in cancer cells and can lead to the silencing of genes with tumor suppressor activities. The isoform A of the Ras-association domain family member 1 (RASSF1A) gene is one ...
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines
(Landes Bioscience, 2011-12-01)
Epigenetic mechanisms are frequently deregulated in cancer cells and can lead to the silencing of genes with tumor suppressor activities. The isoform A of the Ras-association domain family member 1 (RASSF1A) gene is one ...
Epigenetic regulation of the ribosomal cistron seasonally modulates enrichment of H2A.Z and H2A.Zub in response to different environmental inputs in carp (Cyprinus carpio)
(2013)
BACKGROUND: The specific deposition of histone variants into chromatin is an important epigenetic mechanism that contributes to gene regulation through chromatin architectural changes. The histone variant H2A.Z is essential ...
Nutrients and Gene Expression in Development
(ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD, 2020)
Development encompasses the formation of a complex organism starting from a unicellular zygote. This process requires finely tuned changes in gene expression across several cells and tissues, which may be regulated by a ...
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
(2017)
Expression of Dlg4, which encodes the postsynaptic receptor clustering protein PSD95, is decreased in ageing and Alzheimer's disease. Bustos et al. engineer a zinc finger protein that modifies Dlg4 expression by changing ...
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
(2017)
Expression of Dlg4, which encodes the postsynaptic receptor clustering protein PSD95, is decreased in ageing and Alzheimer's disease. Bustos et al. engineer a zinc finger protein that modifies Dlg4 expression by changing ...
Histone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression
(Rockefeller University Press, 2015-11)
In vertebrates, the inner ear arises from the otic placode, a thickened swathe of ectoderm that invaginates to form the otic vesicle. We report that histone demethylase KDM4B is dynamically expressed during early stages ...