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The impact of aged microglia on d-serine-regulated glutamatergic transmission
(Elsevier, 2021-01-01)
Microglia serve a pivotal role in the regulation of the brain environment in neuroinflammation. Their activation depends on highly regulated mechanisms involving various ligands, and pro- and antiinflammatory cytokines. ...
Systematic Production of Inactivating and NonInactivating Suppressor Mutations at the relA Locus That Compensate the Detrimental Effects of Complete spoT Loss and Affect Glycogen Content in Escherichia coli
(Public Library Of Science, 2014-09)
In Escherichia coli, ppGpp is a major determinant of growth and glycogen accumulation. Levels of this signaling nucleotide are controlled by the balanced activities of the ppGpp RelA synthetase and the dual-function ...
Detrimental Effects of HMGB-1 Require Microglial-Astroglial Interaction: Implications for the Status Epilepticus -Induced Neuroinflammation
(Frontiers Media, 2021)
Temporal Lobe Epilepsy (TLE) is the most common form of human epilepsy and available treatments with antiepileptic drugs are not disease-modifying therapies. The neuroinflammation, neuronal death and exacerbated plasticity ...
Mammalian Target of Rapamycin Inhibition in Trypanosoma cruzi-Infected Macrophages Leads to an Intracellular Profile That Is Detrimental for Infection
(Frontiers Media S.A., 2018-02)
The causative agent of Chagas' disease, Trypanosoma cruzi, affects approximately 10 million people living mainly in Latin America, with macrophages being one of the first cellular actors confronting the invasion during T. ...
Oral Leptin Treatment in Suckling Rats Ameliorates Detrimental Effects in Hypothalamic Structure and Function Caused by Maternal Caloric Restriction during Gestation
(Public Library of Science, 2013-11)
A poor prenatal environment brings about perturbations in leptin surge and hypothalamic circuitry that program impaired ability to regulate energy homeostasis in adulthood. Here, using a rat model of moderate maternal ...
Unhealthy diet intake during the peri-natal and adult periods: detrimental neuroendocrine and metabolic effects
(Nova Science Publishers, Inc, 2012)
Consumption of unhealthy diets (so called ¨modern diets¨) in early/late life might play a key role in the development of obesity, metabolic syndrome (MS) and type 2 diabetes (T2DM). Due to the epidemic growth profile of ...
The detrimental influence of bacteria (E. coli, Shigella and Salmonella) on the degradation of organic compounds (and vice versa) in TiO2 photocatalysis and near-neutral photo-Fenton processes under simulated solar light
(Royal Society of Chemistry, 2012-05)
TiO2 photocatalytic and near-neutral photo-Fenton processes were tested under simulated solar light to degrade two models of natural organic matter - resorcinol (R) (which should interact strongly with TiO2 surfaces) and ...
Lipopolysaccharide (LPS) from E. coli has detrimental effects on the intestinal morphology of weaned pigsEl lipopolisacárido (LPS) de E. coli deteriora los parámetros morfológicos intestinales de cerdos posdestete
(Universidad de Antioquia, Facultad de Ciencias AgrariasGrupo de Investigación en Ciencias Agrarias (GRICA)Medellín, Colombia, 2018)