Buscar
Mostrando ítems 91-100 de 7025
The current drug discovery landscape for trypanosomiasis and leishmaniasis: challenges and strategies to identify drug targets
(Willey Periodicals, 2020)
Human trypanosomiasis and leishmaniasis are vector-borne neglected tropical diseases caused by infection with the protozoan parasites Trypanosoma spp. and Leishmania spp., respectively. Once restricted to endemic areas, ...
Promising nanotherapy in treating leishmaniasis
(2018-08-25)
Leishmaniases are infectious diseases caused by an intracellular protozoan in humans by 20 different species of Leishmania among more than 53 species. There are at least twelve million cases of infections worldwide and ...
In silico REPOSITIONING OF NEW DRUGS AGAINST Schistosoma mansoni
(Universidade Federal de Goiás, 2018)
TDR Targets 6: driving drug discovery for human pathogens through intensive chemogenomic data integration
(Oxford University Press, 2019-11)
The volume of biological, chemical and functional data deposited in the public domain is growing rapidly, thanks to next generation sequencing and highly-automated screening technologies. These datasets represent invaluable ...
Computational and synthetic target-based approaches to the discovery of novel anticonvulsant compounds
(Bentham Science Publishers, 2021-05)
Background: During the past decades, an important number of anticonvulsant drugs have been incorporated into the collection of drugs to treat epilepsy. However, two main difficulties remain unsolved in therapy: the development ...
Cys-loop receptors in Caenorhabditis elegans as pharmacological drug targets (Simposio)
(Fundación Revista Medicina, 2019)
The free-living nematode Caenorhabditis elegans has emerged as a powerful model for the study of the nervous system and human diseases and as a model for antiparasitic drug discovery. This nematode has also shown promise ...
Exploiting the natural properties of extracellular vesicles in targeted delivery towards specific cells and tissues
(MDPI, 2020)
Extracellular vesicles (EVs) are important mediators of intercellular communication that participate in many physiological/pathological processes. As such, EVs have unique properties related to their origin, which can be ...
A multilayer network approach for guiding drug repositioning in neglected diseases
(Public Library of Science, 2016-01)
Drug development for neglected diseases has been historically hampered due to lack of market incentives. The advent of public domain resources containing chemical information from high throughput screenings is changing the ...