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Mostrando ítems 91-100 de 326
2D-QSAR and 3D-QSAR/CoMSIA studies on a series of (R)-2-((2-(1H-Indol-2-yl)ethyl)amino)-1-phenylethan-1-ol with human β3-adrenergic activity
(2017-03)
The β3 adrenergic receptor is raising as an important drug target for the treatment of pathologies such as diabetes, obesity, depression, and cardiac diseases among others. Several attempts to obtain selective and high ...
Ozone-Induced Lung Injury And Inflammation Are Modulated By Circulating Stress HormonesOzone-induced lung injury and inflammatión are modulated by circulating stress hormones
(2018)
Air pollution has been associated with a wide-range of health effects. Pulmonary effects of acute ozone inhalation have been widely characterized in humans and animals. These include decrements in lung function, neutrophilic ...
Lack of Gαi2 leads to dilative cardiomyopathy and increased mortality in β1-adrenoceptor overexpressing mice
(Oxford University Press, 2015-12)
Aims Inhibitory G (Gi) proteins have been proposed to be cardioprotective. We investigated effects of Gαi2 knockout on cardiac function and survival in a murine heart failure model of cardiac β1-adrenoceptor overexpression. ...
Noradrenergic neurotransmission within the bed nucleus of the stria terminalis modulates the retention of immobility in the rat forced swimming test
(2013-06-01)
The bed nucleus of the stria terminalis (BNST) is a limbic structure that has a direct influence on the autonomic, neuroendocrine, and behavioral responses to stress. It was recently reported that reversible inactivation ...
Noradrenergic neurotransmission within the bed nucleus of the stria terminalis modulates the retention of immobility in the rat forced swimming test
(2013-06-01)
The bed nucleus of the stria terminalis (BNST) is a limbic structure that has a direct influence on the autonomic, neuroendocrine, and behavioral responses to stress. It was recently reported that reversible inactivation ...
Myocardial dysfunction and abnormalities in intracellular calcium handling in obese rats
(2011-09-01)
Background: Several mechanisms have been proposed to contribute to cardiac dysfunction in obesity models, such as alterations in calcium (Ca 2+) handling proteins and β-adrenergic receptors. Nevertheless, the role of these ...
O estresse crônico e a via de sinalização adrenérgica no desenvolvimento da lesão periapical
(Universidade Estadual Paulista (Unesp), 2017-12-01)
Os objetivos deste estudo são: 1) Esclarecer a possível associação entre o estresse crônico e a estimulação do Sistema Nervoso Simpático (SNS) e investigar sua interferência no desenvolvimento e progressão da lesão periapical; ...