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The delicate balance of autophagy in neurodegeneration
(2017)
Macroautophagy is a vesicle process responsible for the degradation of dysfunctional organelles and mis-folded or aggregated proteins. It constitutes an essential pathway for cellular homeostasis maintenance, especially ...
Mitochondrial Ca2+ signals in autophagy
(Elsevier Ltd, 2012)
Macroautophagy (autophagy) is a lysosomal degradation pathway that is conserved from yeast to humans that plays an important role in recycling cellular constituents in all cells. A number of protein complexes and signaling ...
Macroautophagy and the oncogene-induced senescence
(Frontiers, 2014-09)
The oncogene-induced senescence is emerging as a potent tumor suppressor mechanism and as a possible therapeutic target. Macroautophagy is intimately linked to the senescence condition setup, although its role has not been ...
Autophagy and vacuolar biogenesis during the nectary development
(2019-08-01)
Main conclusion: Different autophagy pathways are a driver of vacuolar biogenesis and are development stage specific during the extrafloral nectary development in Citharexylum myrianthum. Abstract: Plant autophagy plays ...
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
(Taylor & Francis inc., 2016)
Secretory Autophagy and Its Relevance in Metabolic and Degenerative Disease
(Frontiers Media S.A., 2020-05)
Proteins to be secreted through so-called “conventional mechanisms” are characterized by the presence of an N-terminal peptide that is a leader or signal peptide, needed for access to the endoplasmic reticulum and the Golgi ...
Negative Modulation of Macroautophagy by Stabilized HERPUD1 is Counteracted by an Increased ER-Lysosomal Network With Impact in Drug-Induced Stress Cell Survival
(2022-03-02)
Macroautophagy and the ubiquitin proteasome system work as an interconnected network in the maintenance of cellular homeostasis. Indeed, efficient activation of macroautophagy upon nutritional deprivation is sustained by ...
Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation
(2011)
Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
The Enigmatic Role of C9ORF72 in Autophagy
(2017)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by the loss of motor neurons resulting in a progressive and irreversible muscular paralysis. Advances in large-scale genetics and ...