Buscar
Mostrando ítems 1-10 de 123
Cafeteria diet inhibits insulin clearance by reduced insulin-degrading enzyme expression and mRNA splicing
(Bioscientifica LtdBristolInglaterra, 2013)
The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner
(American Society for Cell Biology, 2014-03)
Mammalian insulin-degrading enzyme (IDE) cleaves insulin, among other peptidic substrates, but its function in insulin signaling is elusive. We use the Drosophila system to define the function of IDE in the regulation of ...
Differential Degradation of Amyloid β Genetic Variants Associated with Hereditary Dementia or Stroke by Insulin-degrading Enzyme
(American Society for Biochemistry and Molecular Biology, 2003-06)
Inherited amino acid substitutions at position 21, 22, or 23 of amyloid beta (Abeta) lead to presenile dementia or stroke. Insulin-degrading enzyme (IDE) can hydrolyze Abeta wild type, yet whether IDE is capable of degrading ...
Degradation of soluble amyloid beta-peptides 1-40, 1-42, and the Dutch variant 1-40Q by insulin degrading enzyme from Alzheimer disease and control brains.
(Springer/Plenum Publishers, 2000-12)
Insulin degrading enzyme (IDE) is a metalloprotease that has been involved in amyloid beta peptide (A(beta)) degradation in the brain. We analyzed the ability of human brain soluble fraction to degrade A(beta) analogs 1-40, ...
Proteolytically inactive insulin-degrading enzyme inhibits amyloid formation yielding non-neurotoxic ABeta peptide aggregates
(Public Library of Science, 2013-04-11)
Insulin-degrading enzyme (IDE) is a neutral Zn(2+) peptidase that degrades short peptides based on substrate conformation, size and charge. Some of these substrates, including amyloid â (Aâ) are capable of self-assembling ...
Insulin-degrading enzyme: Structure-function relationship and its possible roles in health and disease
(Bentham Science Publishers, 2009-11)
Insulin-degrading enzyme (IDE) or insulysin is a highly conserved Zn 2+-dependent endopeptidase with an "inverted" HxxEH motif. In vivo, IDE contributes to regulate the steady state levels of peripheral insulin and cerebral ...
Effects of experimental intracerebral ventricular injection of amyloid beta peptide (1-42) aggregates on daily rhythms of Aβ-degrading enzymes in the hippocampus: Relevance to Alzheimer's disease pathophysiology
(Elsevier, 2019-09)
One of the main pathological features in the Alzheimer disease (AD) is the presence of senile plaques, primarily composed of Aβ peptide aggregates, in cortex and hippocampus. AD late onset, which constitutes 90% of cases, ...
Transcriptional regulation of insulin-degrading enzyme modulates mitochondrial amyloid β (Aβ) peptide catabolism and functionality
(American Society For Biochemistry And Molecular Biology, 2013-05)
Studies of post-mortem brains from Alzheimer disease patients suggest that oxidative damage induced by mitochondrial amyloid β (mitAβ) accumulation is associated with mitochondrial dysfunction. However, the regulation of ...