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Estudos de dimerização de peptídeos e os efeitos na inibição da atividade de DNA topoisomerases
(Universidade Estadual Paulista (Unesp), 2021-06-16)
As doenças infeciosas estão entre as principais causas de mortalidade em todo o mundo, especialmente devido à crescente disseminação de bactérias patogênicas resistentes aos antimicrobianos atualmente disponíveis. Diante ...
Inhibition of Taq DNA Polymerase and Human Topoisomerase I by Resveratrol Derivatives
(Bentham Science Publishers, 2017-05)
Background: DNA polymerases and topoisomerases are proteins that play a vital part in DNA metabolism such as replication, transcription, recombination, and chromosome segregation during mitosis. For this reason, these ...
Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones
(2001-03-10)
Quinolones constitute a family of compounds with a potent antibiotic activity. The enzyme DNA gyrase, responsible for the replication and transcription processes in DNA of bacteria, is involved in the mechanism of action ...
Two short peptides including segments of subunit A of Escherichia coli DNA gyrase as potential probes to evaluate the antibacterial activity of quinolones
(2001-03-10)
Quinolones constitute a family of compounds with a potent antibiotic activity. The enzyme DNA gyrase, responsible for the replication and transcription processes in DNA of bacteria, is involved in the mechanism of action ...
Síntese, elucidação estrutural, avaliação da interação com DNA, atividades antiproliferativa e anti-topoisomerase de novos derivados de Acridina
(Universidade Federal de PernambucoUFPEBrasilPrograma de Pos Graduacao em Biologia Aplicada a Saude, 2016)
Inhibition of human DNA topoisomerase IB by nonmutagenic ruthenium(II)-based compounds with antitumoral activity
(2016-02-01)
Herein we synthesized two new ruthenium(ii) compounds [Ru(pySH)(bipy)(dppb)]PF6 (1) and [Ru(HSpym)(bipy)(dppb)]PF6 (2) that are analogs to an antitumor agent recently described, [Ru(SpymMe2)(bipy)(dppb)]PF6 (3), where ...
Planejamento in silico e síntese de peptídeos derivados da proteína YjhX: estudos de inibição da atividade de DNA topoisomerases
(Universidade Estadual Paulista (Unesp), 2020-02-19)
O recém-descoberto sistema YjhX-YjhQ bacteriano é um sistema toxina-antitoxina (TA) do tipo II (formado por duas proteínas) que apresenta um grande potencial a ser estudado com o intuito de desenvolver potenciais fármacos, ...
New insights into structural, electronic, reactivity, spectroscopic and pharmacological properties of Bergenin: Experimental, DFT calculations, MD and docking simulations
(2021-05-15)
Bergenin is a polyphenol found in many medicinal plants that presents numerous activities, such as antiulcer, anti-inflammatory, antifungal, anticancer, antimicrobial, antidiabetic, antiviral and antioxidant, being, ...