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Androgen receptor signaling in prostate cancer: Genetic and molecular aspects
(2014-01-01)
The prostate is an accessory sex gland of the male reproductive system, which produces alkaline prostatic fluid, capable of ensuring the spermatic viability to fertilize eggs within the female reproductive system. Functionally, ...
Modulation of androgen receptor protein by culture conditions of human skin fibroblasts
(2002)
Cultures of skin fibroblasts show variation of androgen binding with culture conditions; binding variations are usually avoided by using confluent cultures. In this work, we analysed the effect of cell density and mitogenic ...
Subcellular Localization and Physiological Roles of Androgen Receptor
(Bentham Science Publishers, 2019)
Androgens, such as testosterone and Dihydrotestosterone (DHT), exert theiractions through the Androgen Receptor (AR), a ligand-dependent nuclear transcription factor that belongs to the steroid hormone nuclear receptor ...
The Role of Androgens in Mammals Folliculogenesis
(Universidade Federal do Rio Grande do Sul, 2016)
Androgen receptor in the Mongolian gerbil ventral prostate: Evaluation during different phases of postnatal development and following androgen blockage
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The normal growth, differentiation and maintenance of the morphofunctional integrity of the prostate gland are dependent on the interaction of constant levels of androgens with their receptors. The need to study the responses ...
Androgen receptor in the Mongolian gerbil ventral prostate: Evaluation during different phases of postnatal development and following androgen blockage
(Pergamon-Elsevier B.V. Ltd, 2008-12-01)
The normal growth, differentiation and maintenance of the morphofunctional integrity of the prostate gland are dependent on the interaction of constant levels of androgens with their receptors. The need to study the responses ...
Testosterone-loaded GM1 micelles targeted to the intracellular androgen receptor for the specific induction of genomic androgen signaling
(Elsevier Science, 2020-12)
Androgens play a central role in homeostatic and pathological processes of the prostate gland. At the cellular level, testosterone activates both the genomic signaling pathway, through the intracellular androgen receptor ...
Androgen receptors in human melanoma cell lines IIB-MEL-LES and IIB-MEL-IAN and in human melanoma metastases
(Lippincott Williams, 2002-12)
The presence and characteristics of androgen receptors (AR) have been described by our group in one human melanoma cell line. We now investigated their presence in two other human melanoma cell lines, IIB-MEL-LES and ...
The Role of Androgen Signaling in Male Sexual Development at Puberty
(Oxford University Press, 2021-02)
Puberty is characterized by major changes in the anatomy and function of reproductive organs. Androgen activity is low before puberty, but during pubertal development, the testes resume the production of androgens. Major ...