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alpha 1-acid glycoprotein and alpha 1-antitrypsin as early markers of treatment response in patients receiving the intensive phase of tuberculosis therapy
(ELSEVIER SCIENCE INC, 2009)
The identification of early markers that predict the response to anti-tuberculosis treatment would facilitate evaluation of new drugs and improve patient management. This study aimed to determine whether selected acute ...
Elucidating the mechanism of action of alpha-1-antitrypsin using retinal pigment epithelium cells exposed to high glucose: Potential use in diabetic retinopathy
(Public Library of Science, 2020-02)
Background: Alpha-1-antitrypsin is a protein involved in avoidance of different processes that are seen in diabetic retinopathy pathogenesis. These processes include apoptosis, extracellular matrix remodeling and damage ...
Characterization of yolk sac proteins of Bos indicus cattle embryos
(FUNPEC-EDITORARIBEIRAO PRETO, 2012)
The yolk sac is an embryonic membrane that is essential for the embryo's initial survival in many mammals. It also plays an important role in the production of proteins necessary for development. We studied proteins of the ...
Alpha-1-antitrypsin ameliorates inflammation and neurodegeneration in the diabetic mouse retina
(Academic Press Ltd - Elsevier Science Ltd, 2018-09)
Diabetic retinopathy (DR) is the most common cause of blindness in the working age population. Early events of DR are accompanied by neurodegeneration of the inner retina resulting in ganglion cell loss. These findings ...
Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?
(BioMed Central, 2014-11)
Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte ...
Diagnosing alpha-1 antitrypsin deficiency: Is it beneficial for the prevention or progression of patients with COPD?
(Soc Brasileira Pneumologia Tisiologia, 2016-09-01)
Feasibility of a genotyping system for the diagnosis of alpha1 antitrypsin deficiency: a multinational cross-sectional analysis
(2022)
Introduction: Currently, strategies for improving alpha1 antitrypsin deficiency (AATD) diagnosis are needed. Here we report the performance of a multinational multiplex-based genotyping test on dried blood spots and buccal ...