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Master regulators of epithelial-mesenchymal transition and wnt signaling pathways in juvenile nasopharyngeal angiofibromas
(2021-09-01)
Juvenile nasopharyngeal angiofibroma (JNA) is a rare fibrovascular benign tumor showing an invasive growth pattern and affecting mainly male adolescents. We investigated the role of epithelial–mesenchymal transition (EMT) ...
The importance of the PI3KJAKT/mTOR signaling pathway in canine neoplasms: Literature review
(Univ Austral Chile, Fac Ciencias Veterinarias, 2016-01-01)
The PI3K/AKT/mTOR pathway is related to proliferation, protein synthesis, survival, angiogenesis, apoptosis, and cell motility. Genetic alterations in either activation of oncogenes or inactivation of tumor suppressor make ...
The YAP/TAZ Signaling Pathway in the Tumor Microenvironment and Carcinogenesis: Current Knowledge and Therapeutic Promises
(MDPI, 2022)
The yes-associated protein (YAP) and the transcriptional coactivator with PDZ-binding motif (TAZ) are transcriptional coactivators, members of the Hippo signaling pathway, which play a critical role in cell growth regulation, ...
Gliomas: New perspectives in diagnosis, treatment and prognosis
(Bentham Science Publishers B.V., 2017)
Meformin and LY294002 treatment regulate angiogenesis process through PI3K-MAPK/AKT/mTOR signaling pathways in mammary tumors.
(Amer Assoc Cancer Research, 2018-01-01)
TGF-beta autocrine pathway and MAPK signaling promote cell invasiveness and in vivo mammary adenocarcinoma tumor progression
(Spandidos Publ Ltd, 2012-08)
Breast cancer progression and metastasis have been linked to abnormal signaling by transforming growth factor-beta (TGF-beta) cytokines. In early-stage breast cancers, TGF-beta exhibits tumor suppressor activity by repressing ...
Interaction of p53 with tumor suppressive and oncogenic signaling pathways to control cellular reactive oxygen species production
(Mary Ann Liebert, 2011-09)
p53 is a crucial transcription factor with tumor suppressive properties that elicits its function through specific target genes. It constitutes a pivotal system that integrates information received by many signaling pathways ...