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Altered neutrophil homeostasis in kinin B1 receptor-deficient mice
(Walter de Gruyter & Co, 2001-01-01)
The kallikrein-kinin system is activated during inflammation and plays a major role in the inflammatory process. One of the main mechanisms of kinin action includes the modulation of neutrophil function employing both ...
Oxidative alteration of Trp-214 and Lys-199 in human serum albumin increases binding affinity with phenylbutazone: A combined experimental and computational investigation
(2018-10-01)
Human serum albumin (HSA) is a target for reactive oxygen species (ROS), and alterations of its physiological functions caused by oxidation is a current issue. In this work, the amino-acid residues Trp-214 and Lys-199, ...
The panpulmonate limpet Siphonaria lessonii Blainville, 1827 as a sentinel of contamination in coastal areas of Argentina
(Elsevier Science, 2021-02)
Although some studies have evaluated the use of Siphonaria lessonii as a bioindicator of pollution, no study has identified the effects of human activities on the digestive gland, which is the main centre of detoxification ...
Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
(2019-01-01)
Methylation patterns established and maintained at CpG sites may be altered by single nucleotide polymorphisms (SNPs) within these sites and may affect the regulation of nearby genes. Our aims were to: 1) identify and ...
Neither bovine somatotropin nor growth hormone-releasing factor alters expression of thyroid hormone receptors in liver and mammary tissues
(ELSEVIER SCIENCE INC, 2011)
Physiological effects of thyroid hormones are mediated primarily by binding of triiodothyronine to specific nuclear receptors. Organ-specific changes in production of triiodothyronine from its prohormone, thyroxine, have ...
ER-bound PTP1B is targeted to newly forming cell-matrix adhesions
(Company of Biologists, 2006-04)
Here, we define the mechanism through which protein tyrosine phosphatase 1B (PTP1B) is targeted to cell-matrix adhesion sites. Green fluorescent protein (GFP)-labeled PTP1B bearing the substrate-trapping mutation D181A was ...
Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein
(2005-05-01)
Bacterial DNA gyrase, has been identified as the target of several antibacterial agents, including the coumarin drugs. The coumarins inhibit the gyrase action by competitive binding to the ATP-binding site of DNA gyrase B ...
Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein
(2005-05-01)
Bacterial DNA gyrase, has been identified as the target of several antibacterial agents, including the coumarin drugs. The coumarins inhibit the gyrase action by competitive binding to the ATP-binding site of DNA gyrase B ...
Phosphorylation of Ryanodine Receptors
(Sociedad de Biología de Chile, 2004)