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Hypoxia supports differentiation of terminally exhausted CD8 T cells
(Frontiers Media S.A., 2021-05)
Hypoxia, angiogenesis, and immunosuppression have been proposed to be interrelated events that fuel tumor progression and impair the clinical effectiveness of anti-tumor therapies. Here we present new mechanistic data ...
Expression patterns of peroxiredoxin genes in bronchial epithelial cells exposed to diesel exhaust particles
(2021-06-01)
Several mechanisms have been suggested to explain the adverse effects of air pollutants on airway cells. One such explanation is the presence of high concentrations of oxidants and pro-oxidants in environmental pollutants. ...
CD39 expression defines cell exhaustion in tumor-infiltrating CD8+ T cells
(American Association for Cancer Research, 2018-01-24)
The ability of CD8+ T lymphocytes to eliminate tumors is limited by their ability to engender an immunosuppressive microenvironment. Here we describe a subset of tumor-infiltrating CD8+ T cells marked by high expression ...
CD4+ T cells with an activated and exhausted phenotype distinguish immunodeficiency during aviremic HIV-2 infection
(Lippincott Williams, 2016-10)
Objective: HIV type 2 (HIV-2) represents an attenuated form of HIV, in which many infected individuals remain 'aviremic' without antiretroviral therapy. However, aviremic HIV-2 disease progression exists, and in the current ...
Evaluation of oxidative stress markers in human conjunctival epithelial cells exposed to diesel exhaust particles (DEP)
(Association for Research in Vision and Ophthalmology, 2015-11)
PURPOSE. The aim of this study was to evaluate oxidative stress markers in human conjunctival epithelial cells (IOBA-NHC) exposed to diesel exhaust particles (DEP). METHODS. Reactive oxygen (ROS) and nitrogen (RNS) species ...
CD39 delineates cell exhaustion in human and mouse tumor-infiltrating CD8+ T cells
(American Association for Cancer Research, 2017-10)
The ability of CD8+ T lymphocytes to eliminate tumors is limited by their ability to engender an immunosuppressive microenvironment. Here we describe a subset of tumor-infiltrating CD8+ T cells marked by high expression ...
Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
(bioRxiv, 2021)
T cell exhaustion is associated with failure to clear chronic infections and malignant cells.
Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to
improving immunotherapeutic modalities. ...