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Aging: working memory capacity and spatial strategies in a virtual orientation task
Brain networks involved in working and spatial memory are closely intertwined, outlining a potential relation between these processes, which are also affected in non-pathological aging. Working memory is a pre-requisite ...
Impaired spatial working memory and reduced hippocampal neuronal density in a rat model of neurocysticercosis
(Frontiers, 2023)
Neurocysticercosis (NCC) is the most common parasitic disease affecting the nervous system and is a leading cause of acquired epilepsy worldwide, as well as cognitive impairment, especially affecting memory. The aim of ...
Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats
(Wiley Blackwell Publishing, Inc, 2016-05)
In rats, learning and memory performance decline during aging, which makes this rodent species a suitable model to evaluate therapeutic strategies of potential value for correcting age‐related cognitive deficits. Some of ...
Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer
(Springer, 2018-11)
The specific roles of Notch in progressive adulthood neurodegenerative disorders have begun to be unraveled in recent years. A number of independent studies have shown significant increases of Notch expression in brains ...
Visuospatial Processing Decline Due to Cannabis Consumption in Nondependent High School Students
(Springer, 2020)
Using cannabis (e.g., smoking marijuana) is becoming popular, partly due to a legalization trend across different countries. This tendency has resulted in cannabis consumption being accepted by society as if it were harmless. ...
Cognitive stimulation during lifetime and in the aged phase improved spatial memory, and altered neuroplasticity and cholinergic markers of mice
(ElsevierPhiladelphia, 2013-08)
In the central nervous system, the degree of decline in memory retrieval along the aging process depends on the quantity and quality of the stimuli received during lifetime. The cholinergic system modulates long-term ...
The hyperforin derivative idn5706 occludes spatial memory impairments and neuropathological changes in a double transgenic alzheimers mouse model
(BENTHAM SCIENCE PUBL LTD, 2010)
The use of natural compounds is an interesting stratagem in the search of drugs with therapeutic potential for the treatment of Alzheimer's disease (AD). We report here the effect of the hyperforin derivative (IDN5706, ...