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Rho-kinase activity is upregulated in the skeletal muscle of aged exercised rats
(2019-12-01)
There is a gap in the knowledge regarding the regulation of glucose uptake in skeletal muscle during the development of insulin resistance in the elderly. Rho-Kinase (Rock) signaling has been demonstrated as a crucial ...
Rho Signaling Pathway and Apical Constriction in the Early Lens Placode
(WILEY-BLACKWELL, 2011)
Epithelial invagination in many model systems is driven by apical cell constriction, mediated by actin and myosin II contraction regulated by GTPase activity. Here we investigate apical constriction during chick lens placode ...
Rho kinase cascade activation in circulating leukocytes in patients with diabetes mellitus type 2
(2020)
Abstract
Background
The intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity ...
Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-β1: Role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways
(2006)
Background and Objectives: Myofibroblastic differentiation is an important event in gingival wound healing and chronic inflammation. Transforming frowth factor-β 1 (TGF-β1) is a potent growth factor that has been implicated ...
Rock protein as cardiac hypertrophy modulator in obesity and physical exercise
(2020-08-01)
Obesity and cardiovascular diseases are worldwide public health issues. In this review, we discussed the participation of ROCK protein in cardiac hypertrophy, mainly through the modulation of leptin and insulin signaling ...
Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study
(Frontiers Media S.A., 2018)
Mechanisms of favorable effects of Rho kinase inhibition on myocardial remodeling and systolic function after experimental myocardial infarction in the rat
(2016)
Objective:
The objective of this study was to determine the molecular mechanisms by which cardiac Rho-associated coiled-coil containing protein kinase (ROCK) activation after myocardial infarction (MI) does intervene in ...
RhoA/ROCK signaling is critical to FAK activation by cyclic stretch in cardiac myocytes
(Amer Physiological SocBethesdaEUA, 2005)
Induction of the myofibroblastic phenotype in human gingival fibroblasts by transforming growth factor-b1: role of RhoA-ROCK and c-Jun N-terminal kinase signaling pathways
(Blackwell Munksgaard Ltd, 2006-06-05)
Myofibroblastic differentiation is an important event
in gingival wound healing and chronic inflammation. Transforming frowth factorb
1 (TGF-b1) is a potent growth factor that has been implicated in this process.
Gingival ...
A RhoA Signaling Pathway Regulates Dendritic Golgi Outpost Formation
(2015)
The neuronal Golgi apparatus (GA) localizes to the perinuclear region and dendrites as tubulo-vesicular structures designated Golgi outposts (GOPs). Current evidence suggests that GOPs shape dendrite morphology and serve ...