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Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
Uncontrolled SFK-mediated protein trafficking in prion and Alzheimer's disease
(Taylor and Francis, 2016)
Prions and Amyloid beta (Aβ) peptides induce synaptic damage via complex mechanisms that include the pathological alteration of intracellular signaling cascades. The host-encoded cellular prion protein (PrPC) acts as a ...
Peptide prodrugs for the treatment of CNS disorders: A perspective for new drugs
(2014-01-01)
The treatment of central nervous system (CNS) diseases is a major challenge. The presence of the barrier intended to protect the brain from unwanted molecules also impairs the efficacy of CNS-targeted drugs. The discovery ...
Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
(Bentham Science Publ Ltd, 2014-01-01)
The treatment of central nervous system (CNS) diseases is a major challenge. The presence of the barrier intended to protect the brain from unwanted molecules also impairs the efficacy of CNS-targeted drugs. The discovery ...
Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
(Elsevier Masson SAS, 2018)
Mecanismos de ação e controle da digestão de proteínas e peptídios em humanos
(1999-12-01)
This review aims to report the major control mechanisms of protein and peptides digestion of special interest in human patients. Regarding protein assimilation its digestive process begins at the stomach with some not so ...
Mecanismos de ação e controle da digestão de proteínas e peptídios em humanos
(1999-12-01)
This review aims to report the major control mechanisms of protein and peptides digestion of special interest in human patients. Regarding protein assimilation its digestive process begins at the stomach with some not so ...
Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
(Bentham Science Publ Ltd, 2014)
Peptide Prodrugs for the Treatment of CNS Disorders: A Perspective for New Drugs
(Bentham Science Publ Ltd, 2014)