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Mostrando ítems 1-10 de 25
A Novel Organotellurium Compound (RT-01) as a New Antileishmanial Agent
(KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI, 2009)
Leishmaniasis is a neglected disease and endemic in developing countries. A lack of adequate and definitive chemotherapeutic agents to fight against this infection has led to the investigation of numerous compounds. The ...
Avaliação toxicológica de organocalcogênios em eritrócitos humanos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2009-07-18)
The interest in organochalcogen chemistry, biochemistry and pharmacology has increased in the last two decades mainly due to the fact that a variety of organochalcogen compounds possess biological activity and due the use ...
Avaliação toxicológica de compostos orgânicos de telúrio sobre o desenvolvimento pré-natal em camundongos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2011-03-25)
It is known that most chemical agents readily cross the placenta and thus may be considered that maternal exposure to external agents can result in toxic effects on embryo-fetal organism. Considering the chemical characteristics ...
Toxicologia e farmacologia in vitro de novos compostos orgânicos de selênio e telúrio com atividade tipo tiol peroxidase
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2009-05-08)
Glutathione peroxidase (GPx; EC 1.11.1.9) is a well-known selenoenzyme that catalyzes the reduction of hydrogen peroxide and some organic hydroperoxides by glutathione (GSH) and protects lipid membranes and other cellular ...
A glimpse on biological activities of tellurium compounds
(Academia Brasileira de Ciências, 2009-09-01)
Tellurium is a rare element which has been regarded as a toxic, non-essential trace element and its biological role is not clearly established to date. Besides of that, the biological effects of elemental tellurium and ...
Negishi cross-coupling of organotellurium compounds: synthesis of biaryls, aryl-, and diaryl acetylenes
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
A functional group tolerant palladium-catalyzed Negishi coupling of diaryl tellurides with organozinc has been developed. This methodology permits efficient preparation of biaryls, aryl acetylenes and diaryl acetylenes in ...
Bcl-2 expression and apoptosis induction in human HL60 leukaemic cells treated with a novel organotellurium(IV) compound RT-04
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
Organotellurium(]V) compounds have been reported to have multiple biological activities including cysteine protease-inhibitory activity, mainly cathepsin B. As cathepsin B is a highly predictive indicator for prognosis and ...
Avaliação da atividade antioxidante de diferentes classes de compostos contra a oxidação de lipoproteínas de baixa densidade
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2011-10-04)
Abnormalities of lipid metabolism often lead to pathologic lipid accumulation in the
vessel wall, oxidative and chronic inflammatory sequelae and the formation of atherosclerotic
lesions, ultimately leading to clinical ...