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First chemoenzymatic synthesis of organoselenium amines and amides
(PERGAMON-ELSEVIER SCIENCE LTD, 2008)
A series of organoselenium amines have been synthesized and submitted to the enzymatic kinetic resolution by acetylation mediated by CAL-B (Novozym 435) to give the corresponding chiral amides in an enantiomerically pure ...
Total synthesis of (+/-)-dihydroactinidiolide using selenium-stabilized carbenium ion
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
A new, short total synthesis of dihydroactinidiolide 1 is described using selenium carbenium ion-promoted carbon-carbon bond formation as the key step. Our synthetic strategy starts with a lactonization reaction between ...
Expression of the ubiE gene of Geobacillus stearothermophilus V in Escherichia coli K-12 mediates the evolution of selenium compounds into the headspace of selenite- and selenate-amended cultures
(Elsevier [Former Publisher] Federation of European Biochemical Societies [Associate Organisation] Wiley [Commercial Publisher], 2006-01)
The ubiE gene of Geobacillus stearothermophilus V, with its own promoter, was cloned and introduced into Escherichia coli. The cloned gene complemented the ubiE gene deficiency of E. coli AN70. In addition, the expression ...
Efeitos de compostos orgânicos de selênio frente à toxicidade induzida por glutamato e metilmercúrio
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2012-03-02)
Organoselenium compounds have been proposed as potential pharmacological agents in the treatment of diseases associated with the oxidative stress. Particularly, ebselen and diphenyl diselenide has been demonstrated as ...
Avaliação toxicológica de organocalcogênios em eritrócitos humanos
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2009-07-18)
The interest in organochalcogen chemistry, biochemistry and pharmacology has increased in the last two decades mainly due to the fact that a variety of organochalcogen compounds possess biological activity and due the use ...
Síntese e avaliação da atividade antioxidante de 1,3,4-oxadiazóis e 1,3,4-tiadiazóis contendo os grupos (2-metiltiazolil-4-il), (5-aril-1,3,4-oxadiazol-2- il) e (4-arilseleno)metiltio na posição-5
(Universidade Federal de Santa MariaBrasilQuímicaUFSMPrograma de Pós-Graduação em QuímicaCentro de Ciências Naturais e Exatas, 2015-07-31)
In the present work, were synthesized thirty three compounds utilizing some
cores, with his derivatives present an antioxidant activity previously described, to
obtain the final products. The organoselenium, the oxadiazoles, ...
Toxicologia e farmacologia in vitro de novos compostos orgânicos de selênio e telúrio com atividade tipo tiol peroxidase
(Universidade Federal de Santa MariaBRBioquímicaUFSMPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, 2009-05-08)
Glutathione peroxidase (GPx; EC 1.11.1.9) is a well-known selenoenzyme that catalyzes the reduction of hydrogen peroxide and some organic hydroperoxides by glutathione (GSH) and protects lipid membranes and other cellular ...