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Intrauterine programming of lipid metabolic alterations in the heart of the offspring of diabetic rats is prevented by maternal diets enriched in olive oil
(Wiley-VCH, 2015-08)
Scope: Maternal diabetes can program metabolic and cardiovascular diseases in the offspring. The aim of this work was to address whether an olive oil supplemented diet during pregnancy can prevent lipid metabolic alterations ...
Olive oil supplementation prevents extracellular matrix deposition and reduces prooxidant markers and apoptosis in the offspring´s heart of diabetic rats
(Pergamon-Elsevier Science Ltd, 2020-08)
Maternal diabetes induces fetal programming of cardiovascular diseases. Diabetes induced-cardiac fibrosis is a process that may start in utero and may be related to the prooxidant/proinflammatory environment. The aim of ...
Pro-oxidant/pro-inflammatory alterations in the offspring´s heart of mild diabetic rats are regulated by maternal treatments with a mitochondrial antioxidant
(Pergamon-Elsevier Science Ltd, 2017-10)
Maternal diabetes programs metabolic and cardiovascular diseases in the offspring. Here, we demonstrated increased pro-oxidant/pro-inflammatory markers in the heart of 2-day-old offspring of diabetic rats, previous to the ...
Intrauterine Programming of Cardiovascular Diseases in Maternal Diabetes
(Frontiers Media, 2021-11)
Maternal diabetes is a prevalent pathology that increases the risk of cardiovascular diseases in the offspring, the heart being one of the main target organs affected from the fetal stage until the adult life. Metabolic, ...
Autonomic and renal alterations in the offspring of sleep-restricted mothers during late pregnancy
(Atha Comunicacao & Editora, 2016)
OBJECTIVES: Considering that changes in the maternal environment may result in changes in progeny, the aim of this study was to investigate the influence of sleep restriction during the last week of pregnancy on renal ...
Alterações cardiorrespiratórias na prole de ratas submetidas à dieta hiperlipídica
(Universidade Federal de São CarlosUFSCarPrograma Interinstitucional de Pós-Graduação em Ciências Fisiológicas - PIPGCFCâmpus São Carlos, 2018-12-14)
In recent decades obesity has become a worldwide epidemic. It has been shown that excessive adipose tissue favors the development of associated diseases such as hypertension, type II diabetes and ventilatory changes. In ...
Increased sympathetic activity in normotensive offspring of malignant hypertensive parents compared to offspring of normotensive parents
(Associação Brasileira de Divulgação Científica, 2008)
Malignant hypertension seems to be the consequence of very high blood pressure. Furthermore, an increase in sympathetic and renin-angiotensin system activity is considered to be the main mechanisms producing malignant ...
Prenatal exposure to gestational diabetes mellitus increases developmental defects in the enamel of offspring
(2019-02-01)
Background and objective Gestational diabetes mellitus (GDM) is associated with short- and long-term maternal and perinatal repercussions. Our objective was to evaluate the long-term consequences of intrauterine exposure ...
Effect of gestational protein restriction on left ventricle hypertrophy and heart angiotensin II signaling pathway in adult offspring rats
(2013)
Maternal protein restriction may be a risk factor for cardiovascular disorders in adulthood. The RAS (renin-angiotensin-system) plays a pivotal role in cardiac remodeling. Components of the RAS, including angiotensin II ...
Maternal melatonin: Effective intervention against developmental programming of cardiovascular dysfunction in adult offspring of complicated pregnancy
(Wiley, 2021)
Adopting an integrative approach, by combining studies of cardiovascular function
with those at cellular and molecular levels, this study investigated whether
maternal treatment with melatonin protects against programmed ...