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Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion
(Cell Press, 2021-09-21)
Although mutations leading to a compromised nuclear envelope cause diseases such as muscular dystrophies or accelerated aging, the consequences of mechanically induced nuclear envelope ruptures are less known. Here, we ...
De novo lipogenesis at the mitotic exit is used for nuclear envelope reassembly/expansion: Implications for combined chemotherapy
(Landes Bioscience, 2019-07-15)
Mitosis has been traditionally considered a metabolically inactive phase. We have previously shown, however, that extensive alterations in lipids occur as the cells traverse mitosis, including increased de novo fatty acid ...
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
The Role of the Nuclear Envelope Protein MAN1 in Mesenchymal Stem Cell Differentiation
(DeepDyve, 2017-04)
Mutations in MAN1, a protein of the nuclear envelope, cause bone phenotypes characterized by hyperostosis. The mechanism of this proosteogenic
phenotype remains unknown. We increased and decreased MAN1 expression in ...
Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopy
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2010)
The receptors for the second messenger InsP(3) comprise a family of closely related ion channels that release Ca(2+) from intracellular stores, most prominently the endoplasmic reticulum and its extension into the nuclear ...
Suppressing aneuploidy-associated phenotypes improves the fitness of Trisomy 21 Cells
(Elsevier B.V., 2019-11)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular ...
Nuclear Architecture of Mouse Spermatocytes: Chromosome Topology, Heterochromatin, and Nucleolus
(S. Karger AG, 2017)
© 2017 S. Karger AG, Basel. The nuclear organization of spermatocytes in meiotic prophase I is primarily determined by the synaptic organization of the bivalents that are bound by their telomeres to the nuclear envelope ...
Carrier-envelope phase dependence in atomic ionization by short-laser pulses
(Elsevier Science, 2009-12)
In atomic ionization by few-cycle laser pulses doubly differential momentum distributions near-threshold exhibit a radial nodal structure that results from peaked partial-wave distributions near a particular angular momentum. ...