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Effect of chronic alcohol drinking on rat liver microsomal nitroreductive metabolism of Nifurtimox and Benznidazole
(Sage Publications Ltd, 2013-12)
Nifurtimox (Nfx) and benznidazole (Bz) have serious toxic side effects. Manufacturers warn about significant adverse effects when simultaneous alcohol consumption is being made, but its mechanism is not known. The levels ...
Nitrofuran drugs beyond redox cycling: Evidence of Nitroreduction-independent cytotoxicity mechanism
(Elsevier, 2020)
Nitrofurans (5-nitro-2-hydrazonylfuran as pharmacophore) are a group of widely used antimicrobial drugs but also associated to a variety of side effects. The molecular mechanisms that underlie the cytotoxic effects of ...
Cyclic voltammetry and digital simulation of the electroreducction of ortho-and meta-nitro aryl 1,4-dihydropyridines
(Sociedad Chilena de Química, 1999)
Cyclic voltammetry (CV) and digital simulation methods are utilezed to elucidate the mechanism of electrochemical reduction of a series of nitro aryl 1,4-dihydropyridines im protic (aqueous) and mixed media. The experimental ...
Nitroreductive metabolic activation of some carcinogenic nitro heterocyclic food contaminants in rat mammary tissue cellular fractions
(Pergamon-Elsevier Science Ltd, 2009-01)
Several nitrofurans and nitroimidazoles have been widely used in veterinary medicine. Some of these compounds are breast carcinogens in rodents and their mechanism of action is hypothesized to be related to reactive ...
Benznidazole biotransformation in rat heart microsomal fraction without observable ultrastructural alterations: comparison to Nifurtimox-induced cardiac effects
(Fundação Oswaldo Cruz, 2008-09)
Benznidazole (Bz) and Nifurtimox (Nfx) have been used to treat Chagas’ disease. Recent studies evidenced cardiotoxic effects of Nfx. We attempted to test whether Bz behaves similarly. Bz reached heart tissue of male rats ...
Cyclic voltammetry and digital simulation of the electroreduction of ortho- and meta-nitro aryl 1,4-dihydropyridines
(1999)
Cyclic voltammetry (CV) and digital simulation methods are utilized to elucidate the mechanism of electrochemical reduction of a series of nitro aryl 1,4-dihydropyridines in protic (aqueous) and mixed media. The experimental ...
Benznidazole-induced ultrastructural and biochemical alterations in rat colon
(Wiley Blackwell Publishing, Inc, 2000-11)
AIM: To study the effects of benznidazole (Bz), a drug used in the chemotherapy of the acute and the intermediate phase of Chagas' disease, on the colon of rats.
METHODS: Sprague Dawley male rats received Bz 100 mg/kg ig. ...
Prevention of benznidazole-induced prolonging effect on the pentobarbital sleeping time of rats using different thiol-containing compounds
(PJD Publications, 2000-07)
Benznidazole (BZ) is a nitroimidazolic chemotherapeutic agent employed against the acute and indeterminate phase of Chagas' disease, a tropical sickness afflicting more than twenty million people in Latin America. BZ has ...
Nifurtimox biotransformation to reactive metabolites or nitrite in liver subcellular fractions and model systems
(Elsevier Ireland, 2002-11)
Liver microsomal (mic); nuclei (N) and mitochondria (mit) anaerobically nitroreduce Nifurtimox (Nfx) in the presence of NADPH generating system. Simultaneous formation of small amounts of nitrite was observed in microsomes ...
Nitroradical anion formation from nitrofurantoin in carbon electrodes
(SOCIEDAD CHILENA DE QUIMICA, 2000-03)
The electrochemical nitroreduction of nitrofurantoin has been studied on carbon paste and glassy carbon electrodes. We can observe a monoelectronic reversible couple ArNO2/ArNO2- and an irreversible peak due to the further ...