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Acetaminophen-induced liver oxidative stress and hepatotoxicity: Influence of Kupffer cell activity assessed in the isolated perfused rat liver
(Maney Publishing, 1997)
The influence of acetaminophen (APAP) treatment (400 mg/kg) on Kupffer cell function was studied in the isolated perfused liver by colloidal carbon infusion, concomitantly with parameters related to oxidative stress ...
Potentiation of ischemia-reperfusion liver injury by hyperthyroidism in the rat
(1997)
Parameters related to hepatic oxidative stress, cell injury, and liver histology were determined in control rats and in animals treated with 3,3',5- triiodothyronine (T3), after in vitro perfusion under normoxic or ischemia- ...
3,3',5-Triiodothyronine-induced hepatic respiration: Effects of desferrioxamine and allopurinol in the isolated perfused rat liver
(1993)
The effect of daily doses of 0.1 mg 3,3',5-triiodothyronine (T3) kg for three consecutive days on hepatic O2 uptake was studied in the isolated perfused rat liver, in the absence and presence of the antioxidants desferrioxamine ...
Effects of the Kupffer cell inactivator gadolinium chloride on rat liver oxygen uptake and content of mitochondrial cytochromes
(1998)
The effect of gadolinium chloride (GdCl3) on the content of rat liver mitochondrial cytochromes was investigated in relation to the basal rate of O2 uptake and Kupffer cell functioning, assessed in liver perfusion studies. ...
Dose-dependent effects of acute lindane treatment on Kupffer cell function assessed in the isolated perfused rat liver
(1997)
1. Twenty-four hours after lindane exposure (5-60 mg/kg) a dose-dependent increase in the serum and hepatic levels of the insecticide was observed. Both the basal rate of O2 consumption and the sinusoidal efflux of lactate ...
Influence of hyperthyroidism on lindane-induced hepatotoxicity in the rat
(1995)
Parameters related to hepatic oxidative stress, cell injury, phagocytic activity, and liver histology were studied in control rats and in animals subjected to l-3,3′,5-triiodothyronine (T3) and/or lindane administration. ...
Time course study of the influence of acute iron overload on kupffer cell functioning and hepatotoxicity assessed in the isolated perfused rat liver
(1998)
This study tested the hypothesis that acute iron overload (500 mg/kg) alters Kupffer cell functioning by promoting free radical reactions associated with the respiratory burst of liver macrophages, assessed in the isolated ...
Pharmacokinetics and hepatotoxicity of diclofenac using an isolated perfused rat liver
(EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 1997)
Pharmacokinetics and hepatotoxicity of diclofenac was studied in a recirculating model of isolated perfused rat liver. Ten male Sprague-Dawley rat (weighing 230-330 g) livers were perfused for 2 h with 250 mt Krebs-Henseleit ...