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CHARACTERIZATION OF Kiss1 NEURONS USING TRANSGENIC MOUSE MODELS
(PERGAMON-ELSEVIER SCIENCE LTD, 2011)
Humans and mice with loss-of-function mutations of the genes encoding kisspeptins (Kiss1) or kisspeptin receptor (Kiss1r) are infertile due to hypogonadotropic hypogonadism. Within the hypothalamus, Kiss1 mRNA is expressed ...
KISS1R Intracellular Trafficking and Degradation: Effect of the Arg386Pro Disease-Associated Mutation
(ENDOCRINE SOC, 2011)
The goal of this study was to investigate how the Arg386Pro mutation prolongs KiSS-1 receptor (KISS1R) responsiveness to kisspeptin, contributing to human central precocious puberty. Confocal imaging showed colocalization ...
A novel homozygous splice acceptor site mutation of KISS1R in two siblings with normosmic isolated hypogonadotropic hypogonadism
(BIOSCIENTIFICA LTD, 2010)
Context: Loss-of-function mutations of the kisspeptin-1 receptor gene, KISS1R, have been identified in patients with normosmic isolated hypogonadotropic hypogonadism (nIHH). Objective: To investigate KISS1R defects in ...
Impaired GABAB receptor signaling dramatically up-regulates Kiss1 expression selectively in nonhypothalamic brain regions of adult but not prepubertal mice
(Endocrine Society, 2014-03)
Kisspeptin, encoded by Kiss1, stimulates reproduction and is synthesized in the hypothalamic anteroventral periventricular and arcuate nuclei. Kiss1 is also expressed at lower levels in the medial amygdala (MeA) and bed ...
Characterization of individual aerosol particles from the eruption of Lonquimay volcano in Chile
(Elsevier Science Publishers B.V., 1999)
A set of aerosol samples collected during major volcanic activities around the Chilean site Lonquimay in the years 1988-1990 has been subjected to measurements in conventional and microPIXE modes in the Debrecen institute. ...
Estradiol-dependent and -independent stimulation of KIss1 expression in the amygdala, BNST, and lateral septum of mice
(Endocrine Society, 2018-09)
Kisspeptin, encoded by Kiss1, activates reproduction by stimulating GnRH neurons. Although most Kiss1 neurons are located in the hypothalamus, smaller Kiss1 populations also reside in the medial amygdala (MeA), bed nucleus ...
GABAB receptor antagonism from birth to weaning permanently modifies Kiss1 expression in hypothalamus and gonads in mice
(Karger, 2021-12)
The kisspeptin gene Kiss1 is expressed in two hypothalamic areas: anteroventral periventricular nucleus/periventricular nucleus (AVPV/PeN) and arcuate nucleus (ARC), and also in gonads. Several pieces of evidence suggests ...