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IGF1 gene therapy reversed cognitive deficits and restored hippocampal alterations after chronic spinal cord injury
(Springer Nature, 2021-12)
The hippocampus is implicated in the generation of memory and learning, processes which involve extensive neuroplasticity. The generation of hippocampal adult-born neurons is particularly regulated by glial cells of the ...
Igf-1 gene therapy as a potentially useful therapy for spontaneous prolactinomas in senile rats
(Bentham Science Publishers, 2018-08)
Background: Insulin-like Growth Factor1 (IGF1) is a powerful neuroprotective molecule. We have previously shown that short-term hypothalamic IGF1 gene therapy restores tuberoinfundibu-lar dopaminergic neuron function in ...
IGF1 Gene Therapy Modifies Microglia in the Striatum of Senile Rats
(Frontiers Research Foundation, 2019-03-05)
Microglial cells become dystrophic with aging; this phenotypic alteration contributes to basal central nervous system (CNS) neuroinflammation being a risk factor for age related neurodegenerative diseases. In previous ...
IGF-I Gene Therapy in Aging Rats Modulates Hippocampal Genes Relevant to Memory Function
(Gerontological Soc Amer, 2017-06)
In rats, learning and memory performance decline during normal aging, which makes this rodent species a suitable model to evaluate therapeutic strategies. In aging rats, insulin-like growth factor-I (IGF-I), is known to ...
Insulin-like growth factor-I gene therapy increases hippocampal neurogenesis, astrocyte branching and improves spatial memory in female aging rats
(Wiley Blackwell Publishing, Inc, 2016-05)
In rats, learning and memory performance decline during aging, which makes this rodent species a suitable model to evaluate therapeutic strategies of potential value for correcting age‐related cognitive deficits. Some of ...