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Carbon monoxide: from toxin to endogenous modulator of cardiovascular functions
(Associação Brasileira de Divulgação Científica, 1999-01-01)
Carbon monoxide (CO) is a pollutant commonly recognized for its toxicological attributes, including CNS and cardiovascular effects. But CO is also formed endogenously in mammalian tissues. Endogenously formed CO normally ...
Immune modulation by inhibitors of the HO system
(MDPI AG, 2021-01)
The heme oxygenase (HO) system involves three isoforms of this enzyme, HO-1, HO-2, and HO-3. The three of them display the same catalytic activity, oxidating the heme group to produce biliverdin, ferrous iron, and carbon ...
Naturally Derived Heme-Oxygenase 1 Inducers and Their Therapeutic Application to Immune-Mediated Diseases
(Frontiers Media S.A., 2020-07)
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. ...
Short repeats in the heme oxygenase 1 gene promoter is associated with increased levels of inflammation, ferritin and higher risk of type-2 diabetes mellitus
(Elsevier GMBH, 2016)
Objective: We evaluated the relationship between the HO1 genotype, ferritin levels and the risk of type-2 diabetes and inflammation.
Research methods: Eight hundred thirty-five individuals were evaluated and classified ...
Naturally derived heme-oxygenase 1 inducers and their therapeutic application to immune-mediated diseases
(Frontiers Media S.A., 2020)
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. ...
Modulation of Antiviral Immunity by Heme Oxygenase-1
(2017)
Heme oxygenase-1 (H0-1) is a stress-inducible, anti-inflammatory, and cytoprotective enzyme expressed in most cell types in the organism. Under several stress stimuli, HO-1 expression and activity is up-regulated to catalyze ...