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Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
(2015-11-01)
Mitochondrial dysfunction is regarded as a hallmark of cancer progression. In the current study, we evaluated mitochondrial genome instability and copy number in colorectal cancer using Next Generation Sequencing approach ...
Using telomeric chromosomal aberrations to evaluate clastogen-induced genomic instability in mammalian cells
(Springer, 2020-12)
Telomeres, the specialized nucleoproteic complexes localized at the physical ends of linear eukaryotic chromosomes, play a fundamental role in maintaining chromosomal stability and integrity, being one of the leading ...
Analysis of genomic instability in adult-onset celiac disease patients by microsatellite instability and loss of heterozygosis
(Lippincott Williams, 2008-12)
Background and Aims: Malignant complications of celiac disease (CD) include carcinomas and lymphomas. The genetic basis behind cancer development in CD is not known, but acquisition of genetic abnormalities and genomic ...
Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats
(Springer, 2008-10-01)
This study was undertaken to investigate the genomic instability on blood cells during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis by means of single cell gel (comet) and micronucleus assays. Male ...
Genomic instability in blood cells is able to predict the oral cancer risk: an experimental study in rats
(Springer, 2008-10-01)
This study was undertaken to investigate the genomic instability on blood cells during 4-nitroquinoline 1-oxide (4NQO)-induced rat tongue carcinogenesis by means of single cell gel (comet) and micronucleus assays. Male ...
Glutathione S-transferase gene polymorphisms in celiac disease and their correlation with genomic instability phenotype
(Elsevier Masson, 2014-01)
Background and objective: Genomic instability and reduced glutathione S-transferase (GST) activity have been identified as potential risk factors for malignant complications in celiac disease (CD). In this study, we assessed ...
Biomarkers of genome instability and cancer epigenetics
(Springer Verlag (Germany), 2017)
Mitochondrial genome instability in colorectal adenoma and adenocarcinoma
(Springer Verlag, 2017)