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Small-Molecule Ligands that bind the RET receptor activate neuroprotective signals independent of but modulated by coreceptor GFR α 1
(American Society for Pharmacology and Experimental Therapeutics, 2020-08)
Glial cell line-derived neurotrophic factor (GDNF) binds the GFRα1 receptor, and the GDNF-GFRα1 complex binds to and activates the transmembrane RET tyrosine kinase to signal through intracellular Akt/Erk pathways. To ...
Low-dose aspirin does not affect the renal function of microalbuminuric type 2 Diabetic patients
(HCPA/FAMED/UFRGS, 2012)
Role of endogenous nitric oxide in unilateral ureteropelvic junction obstruction in children
(Nature Publishing Group, 2003-12)
Background. Obstructive nephropathy leads to tubulointerstitial fibrosis and loss of renal function. Nitric oxide has been shown to have antifibrotic properties. We examined nitric oxide synthase (NOS) activity and expression ...
Efeitos do tratamento com cromoglicato dissódico nas alterações morfofuncionais associadas ao início da nefropatia diabética experimentalDisodium cromoglycate treatment effects on morphofunctional changes associated with the onset of experimental diabetic nephropathy
(Universidade Federal de UberlândiaBrasilPrograma de Pós-graduação em Biologia Celular e Estrutural Aplicadas, 2021)
Renal overexpression of atrial natriuretic peptide and hypoxia inducible factor-1α as adaptive response to a high salt diet
(Hindawi Publishing Corporation, 2014-02)
In the kidney, a high salt intake favors oxidative stress and hypoxia and causes the development of fibrosis. Both atrial natriuretic peptide (ANP) and hypoxia inducible factor (HIF-1α) exert cytoprotective effects. We ...
Bothrops pauloensis snake venom-derived Asp-49 and Lys-49 phospholipases A2 mediates acute kidney injury by oxidative stress and release of inflammatory cytokines
(2021-01-30)
The envenomation caused by the Bothrops pauloensis snake leads to severe local and systemic effects including acute kidney injury. In this study, we investigated the renal effects by phospholipases A2 (PLA2s), divided into ...
Órtese de tornozelo: efeito sobre variáveis dinamométricas e eletromiográficas durante exercício em intensidade do jogo basquetebol
(Universidade Estadual Paulista (Unesp), 2014-02-11)
The aim of the present study was to investigate the effects of the use of ankle brace and fatigue on peak torque and muscle activation of ankle stabilizer muscles, and on ground force reaction (GFR) in vertical jumps, ...
Órtese de tornozelo: efeito sobre variáveis dinamométricas e eletromiográficas durante exercício em intensidade do jogo basquetebol
(Universidade Estadual Paulista (UNESP), 2014)
Órtese de tornozelo: efeito sobre variáveis dinamométricas e eletromiográficas durante exercício em intensidade do jogo basquetebol
(Universidade Estadual Paulista (Unesp), 2014)