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Membrane adsorption or penetration differentially modulates β-galactosidase activity against soluble substrates
(Elsevier Science, 2002-01)
We investigated if in complex environments, like those where β-galactosidase activity is usually assayed, the kinetics of hydrolysis against soluble substrates could be modulated through enzyme-surface interactions. Kinetic ...
Interactions of flavan-3-ols and procyanidins with membranes: mechanisms and the physiological relevance
(Royal Society of Chemistry, 2015-01)
Flavonoids are a type of phenolic compound widely present in edible plants. A great number of health benefits have been ascribed to flavonoid consumption in the human population. However, the molecular mechanisms involved ...
HsDHODH Microdomain-Membrane Interactions Influenced by the Lipid Composition
(2017-12-14)
Human dihydroorotate dehydrogenase (HsDHODH) enzyme has been studied as selective target for inhibitors to block the enzyme activity, intending to prevent proliferative diseases. The N-terminal microdomain seems to play ...
Erythrocyte alkaline phosphatase in patients with myotonic muscle disorders
(Universidad del Zulia, 2013)
Structural Analysis of the Interaction between Jaburetox, an Intrinsically Disordered Protein, and Membrane Models
(Elsevier Science, 2017-11)
Jack bean urease is entomotoxic to insects with cathepsin-like digestive enzymes, and its toxicity is mainly caused by a polypeptide called Jaburetox (Jbtx), released by cathepsin-dependent hydrolysis of the enzyme. Jbtx ...
Nantenine and papaverine differentially modify synaptosomal membrane enzymes
(Urban & Fischer Verlag, 2000-07-01)
Papaverine (1-[(3,4-Dimethoxyphenyl) methyl]-6,7-dimethoxyisoquinoline) and nantenine (O-methyldomesticine) are chemically related isoquinoline alkaloids displaying similar dose-dependent sedative or convulsant effects, ...
Inactivation of vesicular stomatitis virus through inhibition of membrane fusion by chemical modification of the viral glycoprotein
(2007-01-01)
Membrane fusion is an essential step in the entry of enveloped viruses into their host cells triggered by conformational changes in viral glycoproteins. We have demonstrated previously that modification of vesicular ...
Inactivation of vesicular stomatitis virus through inhibition of membrane fusion by chemical modification of the viral glycoprotein
(2007-01-01)
Membrane fusion is an essential step in the entry of enveloped viruses into their host cells triggered by conformational changes in viral glycoproteins. We have demonstrated previously that modification of vesicular ...