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Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network
(Cell Press, 2018-09)
The proto-oncogenic epidermal growth factor receptor (EGFR) is a tyrosine kinase whose sensitivity to growth factors and signal duration determines cellular behavior. We resolve how EGFR's response to epidermal growth ...
Down-modulation of erbB2 activity is necessary but not enough in the differentiation of 3T3-L1 preadipocytes
(Wiley, 2008-05)
The high incidence of obesity-related pathologies, led to the study of the mechanisms involved in preadipose cell proliferation and differentiation. Here, we demonstrate that modulation of erbB2, plays a fundamental ...
Avaliação do significado clínico do subtipo basal-like de câncer de mama identificado através de imunohistoquímica
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2007)
Base teórica: Atualmente, a avaliação prognóstica do câncer de mama inicial é principalmente baseada nas características clínicas das pacientes e histológicas dos tumores. Recentemente, subtipos moleculares de carcinoma ...
Avaliação do significado clínico do subtipo basal-like de câncer de mama identificado através de imunohistoquímica
(Pontifícia Universidade Católica do Rio Grande do SulPorto Alegre, 2007)
Base teórica: Atualmente, a avaliação prognóstica do câncer de mama inicial é principalmente baseada nas características clínicas das pacientes e histológicas dos tumores. Recentemente, subtipos moleculares de carcinoma ...
Identification of resistance mechanism to targeting of the ADAM 17/ EGFR axis in triple negative breast cancer in vivo
(Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica, 2015)
EGFR Tyrosine Kinase Inhibitor (PD153035) Improves Glucose Tolerance and Insulin Action in High-Fat Diet-Fed Mice
(Amer Diabetes AssocAlexandriaEUA, 2009)
Estrogen receptor β and epidermal growth factor receptor as early-stage prognostic biomarkers of non-small cell lung cancer
(Spandidos Publ Ltd, 2010-07)
As 20% of stage I NSCLC patients develop recurrent and often incurable cancer, the identification of prognostic markers has a meaningful clinical application. The biological significance of steroid hormone and EGF receptors, ...
P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study
(F HernandezMurciaEspanha, 2010)
Estrogen receptor-positive breast carcinomas in younger women are different from those of older women: A pathological and immunohistochemical study
(CHURCHILL LIVINGSTONE, 2010)
The higher frequency of triple-negative and HER-2-positive tumors detected in younger patients has been suggested as an explanation for the more aggressive tumor types observed in this age group. However, estrogen receptor ...
Carcinomas mamários de tipo basal: estudo clínicopatológico e imunofenotípico em mulheres brasileiras
(Universidade Federal de Minas GeraisUFMG, 2008-08-11)
Basal-like cancers (BLC) are a newly recognized subtype of breast cancer defined by the expression of genes and proteins characteristic of the myoepithelial/basal cells of normal breast, and have been associated with poor ...