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Evaluation of the biological activity of the disintegrin-like and cysteine-rich domains of Bothropasin, a metalloproteinase from Bothrops jararaca
(Universidade Federal de São CarlosUFSCarPrograma de Pós-Graduação em Química - PPGQCâmpus São Carlos, 2021-05-17)
Bothropasin is a 48kDa hemorrhagic class III Snake Venom Metalloproteinase (SVMP). As a multi-domain protein, it contains catalytic metalloproteinase (M), disintegrin-like (D), and cysteine rich domains (C). Integrins ...
Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom
(Elsevier Science, 2018-07)
Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic ...
Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies
(2003-12)
Snake Venom Metalloproteinases (SVMPs) are synthesized as zymogens and undergo proteolytic processing resulting in a variety of multifunctional proteins. Jararhagin is a P-III SVMP, isolated from the venom of Bothrops ...
Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies
(2003-12)
Snake Venom Metalloproteinases (SVMPs) are synthesized as zymogens and undergo proteolytic processing resulting in a variety of multifunctional proteins. Jararhagin is a P-III SVMP, isolated from the venom of Bothrops ...
Leucurogin, a new recombinant disintegrin cloned from Bothrops leucurus (white-tailed-jararaca) with potent activity upon platelet aggregation and tumor growth
(Elsevier B.V., 2011-07-01)
Disintegrins and disintegrins-like proteins are able to inhibit platelet aggregation and integrin-mediated cell adhesion. the aim of this study was to produce one disintegrin-like cloned from Bothrops leucurus venom gland ...
Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
(2011-08-24)
Hemorrhage is one of the most significant effects in envenomings induced by viperid snakebites. Damage to the microvasculature, induced by snake venom metalloproteinases (SVMPs), is the main event responsible for this ...
Key events in microvascular damage induced by snake venom hemorrhagic metalloproteinases
(2011-08-24)
Hemorrhage is one of the most significant effects in envenomings induced by viperid snakebites. Damage to the microvasculature, induced by snake venom metalloproteinases (SVMPs), is the main event responsible for this ...
Obtenção de uma desintegrina recombinante de Agkistrodon contortrix laticinctus e estudo dos efeitos de desintegrinas na expressão do fator de crescimento de endotélio vascular.
(Universidade Federal de São CarlosBRUFSCarPrograma de Pós-Graduação em Genética Evolutiva e Biologia Molecular - PPGGEv, 2005-02-17)
Disintegrins are snake venom proteins used in the study of integrin-mediated cellular
adhesion through integrins. Recombinant disintegrin production may notable supply faster,
larger and most homogeneous protein samples ...