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Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species
(Elsevier B.V., 2014-03-01)
In the present study, an in silico analysis was performed to identify transposable element (TE) fragments inserted in Cyps with functions associated with resistance to insecticides and developmental regulation as well as ...
Análise da ocorrência de transposição em regiões reguladoras dos genes da família Cyp em espécies de Drosophila
(Universidade Estadual Paulista (Unesp), 2009-04-27)
A resistência aos inseticidas é um modelo de processo evolutivo onde o inseticida atua como agente seletivo e, como resposta à seleção, ocorre a evolução da resistência nas populações de insetos. As enzimas citocromo P450 ...
Análise da ocorrência de transposição em regiões reguladoras dos genes da família Cyp em espécies de Drosophila
(Universidade Estadual Paulista (Unesp), 2009-04-27)
A resistência aos inseticidas é um modelo de processo evolutivo onde o inseticida atua como agente seletivo e, como resposta à seleção, ocorre a evolução da resistência nas populações de insetos. As enzimas citocromo P450 ...
Sustained activation of p53 in confluent nucleotide excision repair-deficient cells resistant to ultraviolet-induced apoptosis
(ELSEVIER SCIENCE BV, 2008)
p53 activation is one of the main signals after DNA damage, controlling cell cycle arrest, DNA repair and apoptosis. We have previously shown that confluent nucleotide excision repair (NER)-deficient cells are more resistant ...
The mitochondrial transcription factor A functions in mitochondrial base excision repair
(ELSEVIER SCIENCE BV, 2010)
Mitochondrial transcription factor A (TFAM) is an essential component of mitochondrial nucleoids TFAM plays an important role in mitochondrial transcription and replication TFAM has been previously reported to inhibit ...
CPDs and 6-4PPs play different roles in UV-induced cell death in normal and NER-deficient human cells
(ELSEVIER SCIENCE BV, 2008)
Ultraviolet (UV) light generates two major DNA lesions: cyclobutane pyrimidine dimers (CPDs) and pyrimidine-(6-4)-pyrimidone photoproducts (6-4PPs), but the specific participation of these two lesions in the deleterious ...
BACH2: A marker of DNA damage and ageing
DNA damage and ageing share expression changes involving alterations in many aspects of metabolism, suppression of growth and upregulation of defence and genome maintenance systems. 'Omics' technologies have permitted ...