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DNA Double-Strand Breaks: A Double-Edged Sword for Trypanosomatids
(2021-04-15)
For nearly all eukaryotic cells, stochastic DNA double-strand breaks (DSBs) are one of the most deleterious types of DNA lesions. DSB processing and repair can cause sequence deletions, loss of heterozygosity, and chromosome ...
The invariance of the total direct DNA strand break yield
(Amer Assoc Physicists Medicine Amer Inst PhysicsMelvilleEUA, 2011)
The natural absence of RPA1N domain did not impair Leishmania amazonensis RPA-1 participation in DNA damage response and telomere protection.
(2013-04-01)
We have previously shown that the subunit 1 of Leishmania amazonensis RPA (LaRPA-1) alone binds the G-rich telomeric strand and is structurally different from other RPA-1. It is analogous to telomere end-binding proteins ...
What's the signification of nuclear vacuoles in human sperm?
(2008-07-01)
The aim of this study was to determine the extent of DNA fragmentation and the presence of single/denatured or double stranded of DNA in sperm with large nuclear vacuoles (LNV) selected by high-magnification. A total of ...
What's the signification of nuclear vacuoles in human sperm?
(2008-07-01)
The aim of this study was to determine the extent of DNA fragmentation and the presence of single/denatured or double stranded of DNA in sperm with large nuclear vacuoles (LNV) selected by high-magnification. A total of ...
Novel properties of melanins include promotion of DNA strand breaks, impairment of repair, and reduced ability to damage DNA after quenching of singlet oxygen
(ELSEVIER SCIENCE INCNEW YORK, 2012)
Melanins have been associated with the development of melanoma and its resistance to photodynamic therapy (PDT). Singlet molecular oxygen (102), which is produced by ultraviolet A solar radiation and the PDT system, is ...
Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair
(2020)
Hereditary mutations in polynucleotide kinasephosphatase
(PNKP) result in a spectrum of neurological
pathologies ranging from neurodevelopmental
dysfunction in microcephaly with early onset
seizures (MCSZ) to ...