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Autophagy in development, cell differentiation, and homeodynamics: From molecular mechanisms to diseases and pathophysiology
(Hindawi Publishing Corporation, 2014-01)
The focus of this special issue is to highlight the role of autophagy in cellular homeodynamics, cell differentiation, and development with an outlook to diseases. Autophagy is an evolutionarily conserved catabolic process ...
Identifying pathophysiological bases of disease in COVID-19
(BioMed Central, 2020-09)
COVID-19 is an infectious disease caused by the SARS-CoV-2 virus that can affect lung physiology encompassing a wide spectrum of severities, ranging from asymptomatic and mild symptoms to severe and fatal cases; the latter ...
Factores de virulencia de Mycobacterium tuberculosis
(Sociedad Médica de Santiago, 2011-12)
Mycobacterium tuberculosis, the etiological agent of human tuberculosis, causes annually three million deaths and latently infects about two billion people. Immunodeficiency caused by malnutrition, senescence or co-infection ...
COVID-19 Cardiovascular Epidemiology, Cellular Pathogenesis, Clinical Manifestations and Management
Coronavirus Disease 2019 (COVID-19) is a rapidly progressing global pandemic that may
present with a variety of cardiac manifestations including, but not limited to, myocardial
injury, myocardial infarction, arrhythmias, ...
Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine: Impact on its function as membrane barrier
(Academic Press Ltd - Elsevier Science Ltd, 2016-07)
The gastrointestinal epithelium functions as a selective barrier to absorb nutrients, electrolytes and water, but at the same time restricts the passage into the systemic circulation of intraluminal potentially toxic ...
Oxidative stress monitoring in in vitro and in vivo models
(2020-01-01)
In aerobic organisms, cellular respiration is an essential process that is divided into several steps. The third and last step is called oxidative phosphorylation, which occurs in the mitochondria, specifically in the inner ...
Lipid Droplets and the Pathophysiology of Liver Diseases
(Nova Science Publishers, 2019)
Lipid droplets (LDs) are widespread intracellular organelles formed by a triglyceride, cholesteryl ester and retinyl ester core surrounded by a monolayer of phospholipids and free (unesterified) cholesterol. LDs number and ...
Cardiac Remodeling: Concepts, Clinical Impact, Pathophysiological Mechanisms and Pharmacologic Treatment
(2016-01-01)
Cardiac remodeling is defined as a group of molecular, cellular and interstitial changes that manifest clinically as changes in size, mass, geometry and function of the heart after injury. The process results in poor ...