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A BK (Slo1) channel journey from molecule to physiology
(Taylor and Francis Inc., 2013)
Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and non-neuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK ...
Differential effects of beta 1 and beta 2 subunits on BK channel activity
(ROCKEFELLER UNIV PRESS, 2005-04)
High conductance, calcium- and voltage-activated potassium (BK) channels are widely expressed in mammals. In some tissues, the biophysical properties of BK channels are highly affected by coexpression of regulatory (beta) ...
A BK (Slo1) channel journey from molecule to physiology
(Taylor & Francis, 2013-09)
Calcium and voltage-activated potassium (BK) channels are key actors in cell physiology, both in neuronal and nonneuronal cells and tissues. Through negative feedback between intracellular Ca2+ and membrane voltage, BK ...
Molecular Determinants Of Bk Channel Functional Diversity And Functioning
(2017)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels play many physiological roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion. BK channels are tetramers in which the pore-forming ...
Activation of human smooth muscle BK channels by hydrochlorothiazide requires cell integrity and the presence of BK β1 subunit
(Nature Publishing Group, 2018-03)
Thiazide-like diuretics are the most commonly used drugs to treat arterial hypertension, with their efficacy being linked to their chronic vasodilatory effect. Previous studies suggest that activation of the large conductance ...
LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells
(National Academy of Sciences, 2019-09)
The perception of sound relies on sensory hair cells in the cochlea that convert the mechanical energy of sound into release of glutamate onto postsynaptic auditory nerve fibers. The hair cell receptor potential regulates ...
β1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
(National Academy of Sciences, 2016)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels are involved in a large variety of physiological processes. Regulatory β-subunits are one of the mechanisms responsible for creating BK channel diversity ...
beta 1-subunit-induced structural rearrangements of the Ca2+- and voltage-activated K+ (BK) channel
(Natl Acad Sciences, 2016)
Large-conductance Ca2+- and voltage-activated K+ (BK) channels are involved in a large variety of physiological processes. Regulatory beta-subunits are one of the mechanisms responsible for creating BK channel diversity ...