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Screening of plants from the Brazilian Atlantic Forest led to the identification of Athenaea velutina (Solanaceae) as a novel source of antimetastatic agents
(2020-06-01)
Plant biodiversity is a source of potential natural products for the treatment of many diseases. One of the ways of discovering new drugs is through the cytotoxic screening of extract libraries. The present study evaluated ...
Antitumour and Antimetastatic Effects and Safety Profile of a New Magnesium(II)-Chrysin Complex
(Csiro Publishing, 2020-02)
Chrysin is a flavone found in many plant extracts including blue passion flower, propolis and honey. The magnesium(II) cation is an essential metal for life and it is involved in a variety of metabolic and physiological ...
Urokinase Exerts Antimetastatic Effects by Dissociating Clusters of Circulating Tumor Cells–Letter
(American Association for Cancer Research, 2016-08)
Blood-borne spread is responsible for the vast majority of cancer-related deaths, and it is recognized that clusters of circulating tumor cells (CTC) are much more likely to cause metastasis than single CTCs. In the November ...
Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells
(Impact Journals, 2018-05-04)
Triple-negative breast cancer (TNBC) is associated with poor prognosis, high local recurrence rate and high rate of metastasis compared with other breast cancer subtypes. In addition, TNBC lacks a targeted therapy. This ...
Novel sulfonamide compounds for inhibition of metastatic tumor growth (WO2012021963)
(Informa Healthcare, 2013)
A series of novel ureido-sulfonamides was prepared by reaction of aminobenzenesulfonamide with alkyl/aryl isocyanate. These compounds are claimed for use as therapeutic agents of metastatic tumors, which are poorly responsive ...
A Penicillin Derivative Exerts an Anti-Metastatic Activity in Melanoma Cells Through the Downregulation of Integrin αvβ3 and Wnt/β-Catenin Pathway
(Frontiers Media, 2020-02)
The synthetic triazolylpeptidyl penicillin derivative, named TAP7f, has been previously characterized as an effective antitumor agent in vitro and in vivo against B16-F0 melanoma cells. In this study, we investigated the ...
Antitumoral and antimetastatic activity of Maitake D-Fraction in triple-negative breast cancer cells
(Fundación Revista Medicina, 2017)
D-Fraction is a proteoglucan extracted from Grifola frondosa (Maitake) mushroom. Previously, we reported that D-Fraction de creases breast cancer (BC) cell viability regardless of hormone receptors and HER2 status of cells. ...
The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer
(Pergamon-elsevier Science Ltd, 2015-09)
The active form of vitamin D3, calcitriol, plays a major role in maintaining calcium/phosphate homeostasis. In addition, it is a potent antiproliferative and prodifferentiating agent. However, when effective antitumor doses ...