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AMPK signaling pathway is rapidly activated by T3 and regulates the cardiomyocyte growth
(North Holland PublishingLimerick, 2013-08-25)
Previous studies have indicated that AMP-activated protein kinase (AMPK) plays a critical role in the control of cardiac hypertrophy mediated by different stimuli such as thyroid hormone (TH). Although the classical effects ...
AKT and AMPK Activation after High-Fat and High-Glucose In Vitro Treatment of Prostate Epithelial Cells
(Georg Thieme Verlag Kg, 2014-06-01)
Considering the increasing consumption of saturated fat and glucose in diets worldwide and its possible association to carcinogenesis, this investigation analysed the proliferation profile of nonmalignant human prostate ...
Investigação da participação da AMPK em aspectos do catabolismo lipídico induzido pela privação alimentar
(Universidade Federal de São Paulo, 2023-05-25)
Objetivo: Investigar a participação da Proteína Quinase Ativada por Adenosina
Monofosfato (AMPK) em aspectos do catabolismo de lipídios induzido pela privação
alimentar. Métodos: A contribuição da β-oxidação para a ...
Involvement of AMPK, IKβα-NFκB and eNOS in the sildenafil anti-inflammatory mechanism in a demyelination model
(Elsevier B. V., 2015)
Sildenafil (Viagra®) has recently been found to have a neuroprotective effect, which occurs through the inhibition of inflammation and demyelination in the cerebellum. However, the mechanism of action of sildenafil remains ...
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
(Wiley Blackwell Publishing, Inc, 2014-02)
5´AMP-activated kinase (AMPK) constitutes a hub for cellular metabolic and growth control, thus representing an ideal therapeutic target for prostate cancers (PCas) characterized by increased lipogenesis and activation of ...
Fueling the engine: induction of AMP-activated protein kinase in trout skeletal muscle by swimming
(Company of Biologists, 2014-05)
AMP-activated protein kinase (AMPK) is well known to be induced by exercise and to mediate important metabolic changes in the skeletal muscle of mammals. Despite the physiological importance of exercise as a modulator of ...
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
(Elsevier, 2016)
Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
Thyroid hormone induced expression of the hepatic scaffold proteins sestrin2, beta Klotho, and FRS2 in relation to FGF21 AMPK signaling
(Johann Ambrosius Barth Verlag Medizinverlage Heidelberg GMBH, 2018)
Thyroid hormone (3,3', 5-triiodothyronine, T-3) accelerates energy metabolism in the liver through mechanisms involving upregulation of AMP-activated protein kinase (AMPK). This study aims to assess the influence of T-3 ...