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Hydrogen bonds and heat diffusion in α‑helices: a computational study
(American Chemical Society, 2014)
Recent evidence has shown a correlation between the heat
diffusion pathways and the known allosteric communication pathways in
proteins. Allosteric communication in proteins is a central, yet unsolved,
problem in ...
Small-Molecule-Induced Soluble Oligomers of α-Synuclein with Helical Structure
(Wiley VCH Verlag, 2017-09)
Accumulation of α-synuclein (αSyn) aggregates constitutes the hallmark of synucleinopathies including Parkinson's disease. However, many steps from the innocuous, monomeric αSyn toward misfolded oligomers and fibrillar ...
Estudio del corte proteolítico y cambio conformacional de la hélice α-1 y α2 del dominio I de la toxina Cry1Ab de Bacillus thuringiensis en la oligomerización in-vitro en Manduca sexta (Gusano cornudo)
(Universidad Nacional José Faustino Sánchez Carrión, 2019)
Objetivo: Determinar de qué manera el corte proteolítico y cambio conformacional de la hélice α-1 y α-2 del dominio I de la toxina Cry1Ab de Bacillus thuringiensis influirán en la oligomerización in-vitro en Manduca sexta. ...
A comparison between internal protein nanoenvironments of α-helices and β-sheets
(2020-12-01)
Secondary structure elements are generally found in almost all protein structures revealed so far. In general, there are more β-sheets than α helices found inside the protein structures. For example, considering the PDB, ...
Small molecule-mediated stabilization of vesicle-associated helical Alpha-synuclein inhibits patogenic misfolding and aggregation
(Nature Publishing Group, 2014-12)
α-synuclein is an abundant presynaptic protein that is important for regulation of synaptic vesicle trafficking, and whose misfolding plays a key role in Parkinson’s disease. While α-synuclein is disordered in solution, ...
Rational design of antiangiogenic helical oligopeptides targeting the vascular endothelial growth factor receptors
(Frontiers Media S.A., 2019-03)
Tumor angiogenesis, essential for cancer development, is regulated mainly by vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs), which are overexpressed in cancer cells. Therefore, the VEGF/VEGFR ...
Charge transport in fibrous/not fibrous -helical and variant peptides
(American Institute of Physics, 2011-01-31)
Modelo não linear de dínamo solar unidimensional
(Universidade Federal de Minas GeraisBrasilICX - DEPARTAMENTO DE FÍSICAPrograma de Pós-Graduação em FísicaUFMG, 2020-03-10)
In this work we study the generation of the large scale magnetic fields observed in cosmic objects using analytical and numerical turbulent mean-field dynamo models. We use a simplified, one-dimensional formulation, with ...
Electronic specific heat of an a3-helical polypeptide and its biochemical variants
(Elsevier, 2012-07-23)