Buscar
Mostrando ítems 1-10 de 1398
Spatial biology of Ising-like synthetic genetic networks
(2023)
Background: Understanding how spatial patterns of gene expression emerge from the interaction of individual gene networks is a fundamental challenge in biology. Developing a synthetic experimental system with a common ...
The CRISPR toolbox for the gram-positive model bacterium Bacillus subtilis
(2021-01-01)
CRISPR has revolutionized the way we engineer genomes. Its simplicity and modularity have enabled the development of a great number of tools to edit genomes and to control gene expression. This powerful technology was first ...
Synthetic and natural polycations for gene therapy: State of the art and new perspectives
(Bentham Science Publ Ltd, 2006-02-01)
Currently, the major drawback of gene therapy is the gene transfection rate. The two main types of vectors that. are used in gene therapy are based on viral or non-viral gene delivery systems. There are several non-viral ...
Gene geography of South America: Testing models of population displacement based on archeological evidence
(1992)
Gene frequencies for 13 marker systems are used to construct synthetic gene frequency maps of South America. The surfaces generated using the first three principal components exhibit clines which validate models of population ...
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae
(2007-05-18)
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular protein known to contain the unusual amino acid residue hypusine. eIF5A has been implicated ...
Use of a synthetic lethal screen to identify genes related to TIF51A in Saccharomyces cerevisiae
(2007-05-18)
The putative eukaryotic translation initiation factor 5A (eIF5A) is an essential protein for cell viability and the only cellular protein known to contain the unusual amino acid residue hypusine. eIF5A has been implicated ...
Expression of codon optimized genes in microbial systems: current industrial applications and perspectives
(Frontiers, 2014-02)
The efficient production of functional proteins in heterologous hosts is one of the major bases of modern biotechnology. Unfortunately, many genes are difficult to express outside their original context. Due to their ...