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THEORETICAL STUDY OF THE OPIOID RECEPTOR SELECTIVITY OF SOME 7-ARYLIDENENALTREXONES
(Sociedad Chilena de Química, 2003)
α4β2 nicotinic receptors with high and low acetylcholine sensitivity: Pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine
(2006)
α4 and β2 nicotinic acetylcholine receptor (nAChR) subunits expressed heterologously assemble into receptors with high (HS) and low (LS) sensitivity to acetylcholine (ACh); their relative proportions depend on the α4 to ...
Molecular chaperones shape steroid receptor action and pharmacologic strategies
(Jacobs Publisher, 2015-03-31)
Chaperone oligomers exist in cell cytosols as preassembled heterocomplexes that function as protein-folding molecular machines able to assemble essential proteins related to families that embrace steroid receptors, ...
Molecular determinants for competitive inhibition of α4β2 nicotinic acetylcholine receptors
(American Society for Pharmacology and Experimental Therapy, 2010)
The Erythrina alkaloids erysodine and dihydro-β-erythroidine (DHβE) are potent and selective competitive inhibitors of α4β2 nicotinic acetylcholine receptors (nAChRs), but little is known about the molecular determinants ...
Cross-talk with β2-adrenoceptors enhances ligand affinity properties from endothelial alpha1D-adrenoceptors that mediates carotid relaxation
(2013-09-01)
Objectives Our main objectives were to investigate the affinity properties of endothelial and muscular α1D-adrenoceptors and to characterize the cross-talk between endothelial α1D- adrenoceptors and β2-adrenoceptors in rat ...
Cross-talk with β2-adrenoceptors enhances ligand affinity properties from endothelial alpha1D-adrenoceptors that mediates carotid relaxation
(2013-09-01)
Objectives Our main objectives were to investigate the affinity properties of endothelial and muscular α1D-adrenoceptors and to characterize the cross-talk between endothelial α1D- adrenoceptors and β2-adrenoceptors in rat ...
Histamine receptors and cancer pharmacology : an update
(WileyBritish Pharmacological Society, 2018)
Abstract: In the present review, we will discuss the recent advances in the understanding of the role of histamine and histamine receptors in cancer biology. The controversial role of the histaminergic system in different ...
Current knowledge and perspectives on histamine H1 and H2 receptor pharmacology: Functional selectivity, receptor crosstalk, and repositioning of classic histaminergic ligands
(American Society for Pharmacology and Experimental Therapeutics, 2016-11)
H1 and H2 histamine receptor antagonists, although developed many decades ago, are still effective for the treatment of allergic and gastric acid-related conditions. This article focuses on novel aspects of the pharmacology ...