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A thermodynamic analysis of the binding specificity between four human pdz domains and eight host, viral and designed ligands
(MDPI AG, 2021-08)
PDZ domains are binding modules mostly involved in cell signaling and cell–cell junctions. These domains are able to recognize a wide variety of natural targets and, among the PDZ partners, viruses have been discovered to ...
Only subtle protein conformational adaptations are required for ligand binding to thyroid hormone receptors: Simulations using a novel multipoint steered molecular dynamics approach
(AMER CHEMICAL SOC, 2008)
Thyroid hormone receptors (TR) are hormone-dependent transcription regulators that play a major role in human health, development, and metabolic functions. The thyroid hormone resistance syndrome, diabetes, obesity, and ...
Structural modeling of high-affinity thyroid receptor-ligand complexes
(SPRINGER, 2010)
Understanding the molecular basis of the binding modes of natural and synthetic ligands to nuclear receptors is fundamental to our comprehension of the activation mechanism of this important class of hormone regulated ...
Structural modeling of high-affinity thyroid receptor-ligand complexes
(SpringerHeidelberg, 2010)
Understanding the molecular basis of the binding modes of natural and synthetic ligands to nuclear receptors is fundamental to our comprehension of the activation mechanism of this important class of hormone regulated ...
A family-based approach reveals the function of residues in the nuclear receptor ligand-binding domain
(Elsevier B.V., 2004-08-06)
Literature studies, 3D structure data, and a series of sequence analysis techniques were combined to reveal important residues in the structure and function of the ligand-binding domain of nuclear hormone receptors. A ...
Impact of human galectin-1 binding to saccharide ligands on dimer dissociation kinetics and structure
(Oxford University Press, 2016-12-05)
Endogenous lectins can control critical biological responses, including cell communication, signaling, angiogenesis and immunity by decoding glycan-containing information on a variety of cellular receptors and the extracellular ...
Structural Insights into the Ligand Binding Domain of the Glucocorticoid Receptor: A Molecular Dynamics Study
(American Chemical Society, 2019-11)
The glucocorticoid receptor (GR) is a ligand-binding dependent transcription factor that ultimately regulates vital biological processes and inflammation response through specific gene expression control, thus representing ...
Identification of a New Hormone-Binding Site on the Surface of Thyroid Hormone Receptor
(Endocrine SocWashingtonEUA, 2014)