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Natural bioactive compounds as adjuvant therapy for hepatitis c infection
(2021-01-01)
Background: Hepatitis C virus infection is a significant global health burden, which causes acute or chronic hepatitis. Acute hepatitis C is generally asymptomatic and progresses to cure, while persistent infection can ...
Plant-derived antivirals against hepatitis c virus infection
(Biomed Central Ltd, 2018-02-13)
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide. There is no effective vaccine for prevention of HCV infection; ...
Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro
(2014)
Compounds extracted from plants can provide an alternative approach to new therapies. They present characteristics such as high chemical diversity, lower cost of production and milder or inexistent side effects compared ...
Beneficial effects of N-acetylcysteine on hepatic oxidative stress in streptozotocin-induced diabetic rats
(2018-01-01)
Diabetes is one of the leading diseases worldwide and, thus, finding new therapeutic alternatives is essential. The development of non-alcoholic fatty liver disease is a notable diabetic complication. Therefore, antioxidant ...
Atividade antiviral de compostos naturais no ciclo replicativo do HCVAntiviral activity of natural compounds in the replicative cycle of HCV
(Universidade Estadual Paulista (Unesp), 2016)
Biliary drug excretion
(Springer, 2021)
Biliary excretion refers to the elimination of endogenous and exogenous compounds (and their metabolites) predominantly by secretion through the canalicular membrane into the canaliculus, a space formed between the apical ...
Quantum chemical study of the relationships between Electronic structure and pharmacokinetic Profile, inhibitory strength toward Hepatitis c virus ns5b Polymerase and hcv replicons of Indole-based Compounds
(Sociedad Chilena de Quimica, 2013)
This paper uses newly developed and extended quantum chemical methods in an attempt to advance the knowledge of the relationship between the variation of several local atomic descriptors of the electronic structure and the ...
Comparative liver morphology associated with the hepatosomatic index in five Neotropical anuran species
(Wiley-Blackwell, 2020-10-28)
The liver is an important metabolic organ in vertebrates. In anurans, the hepatosomatic index (HSI) reflects differences in energy storage and reproductive activities between males and females. The objective of this study ...