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A beginner's guide for FMDV quasispecies analysis: sub-consensus variant detection and haplotype reconstruction using next-generation sequencing
(Oxford University Press, 2020-09)
Deep sequencing of viral genomes is a powerful tool to study RNA virus complexity. However, the analysis of next-generation sequencing data might be challenging for researchers who have never approached the study of viral ...
A beginner's guide for FMDV quasispecies analysis: Sub-consensus variant detection and haplotype reconstruction using next-generation sequencing
(Oxford University Press, 2020-09)
Deep sequencing of viral genomes is a powerful tool to study RNA virus complexity. However, the analysis of next-generation sequencing data might be challenging for researchers who have never approached the study of viral ...
Simulação computacional e análise de um modelo fenotípico de evolução viral
(Universidade Federal de São Paulo (UNIFESP), 2011-01-26)
A large amount of viruses of medical importance such as HIV, respiratory syncytial virus, the hepatitis C virus, influenza A (H1N1) and polio virus, has RNA genome. These viruses exhibit extremely high mutational rate, ...
Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz, 2023)
GB virus C quasispecies detected in plasma and lymphocyte subsets in a natural human infection
(Society for General Microbiology, 2010-07)
Genomic heterogeneity and quasispecies composition of GB virus C (GBV-C) within plasma and lymphocyte subsets in a naturally infected blood donor were investigated. For this purpose, fragments from the 5′ untranslated ...
Inter and intra-host variability of hepatitis C virus genotype 1a hypervariable envelope coding domains followed for a 4-11 year of human immunodeficiency virus coinfection and highly active antiretroviral therapy
(Elsevier, 2014-10)
The evolution of hepatitis C virus (HCV) quasispecies in patients with HIV-1 coinfection is not fully understood. The HCV-1a quasispecies heterogeneity was analyzed at inter and intra-host levels along 7.6 years in 21 ...
Simulação computacional e análise de um modelo de recombinação retroviral
(Universidade Federal de São Paulo (UNIFESP), 2017-04-28)
Retroviruses cause major diseases in humans, such as Acquired Human Immunodeficiency Syndrome (AIDS), caused by HIV-1, which accounts for 2.1 million new cases in 2015 alone, and T-cell lymphoma, caused by HTLV-1. One of ...
Inter and intrapatient evolution of hepatitis C virus
(Mexican Assoc Hepatology, 2015-07)
Hepatitis C virus (HCV) has a short replication time, high mutation rates and large population sizes, all of which make it an excellent experimental model for evolution studies, because evolution can be visualized in ...
Quasispecies of hepatitis C virus genotype 1 and treatment outcome with Peginterferon and Ribavirin
(Elsevier B.V., 2009-07-01)
The majority of patients with chronic hepatitis C fail to respond to antiviral therapy. The genetic basis of this resistance is unknown. The quasispecies nature of HCV may have an important implication concerning viral ...