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On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
(NATURE PUBLISHING GROUPLONDON, 2012)
The search for reconsolidation blockers may uncover clinically relevant drugs for disrupting memories of significant stressful life experiences, such as those underlying the posttraumatic stress disorder. Considering the ...
5-HT2a receptor in mPFC influences context-guided reconsolidation of object memory in perirhinal cortex
(eLife Sciences Publications Ltd, 2018-05)
Context-dependent memories may guide adaptive behavior relaying in previous experience while updating stored information through reconsolidation. Retrieval can be triggered by partial and shared cues. When the cue is ...
Effect of a positive reinforcing stimulus on fear memory reconsolidation in ethanol withdrawn rats: Influence of D-cycloserine
(Elsevier Science, 2016-12)
The pharmacological blockade of memory reconsolidation has been suggested as a potential treatment to the attenuation of maladaptive memories associated to psychiatric disorders and drug addiction. To interfere with the ...
The effect of Midazolam and Propranolol on fear memory reconsolidation in ethanol-withdrawn rats: Influence of D-cycloserine
(Oxford University Press, 2014-01)
Background: Withdrawal from chronic ethanol facilitates the formation of contextual fear memory and delays the onset to extinction, with its retrieval promoting an increase in ethanol consumption. Consequently, manipulations ...
Neuropharmacology of memory consolidation and reconsolidation: insights on central cholinergic mechanisms
(Elsevier, 2014-12)
Central cholinergic system is critically involved in all known memory processes. Endogenous acetylcholine release by cholinergic neurons is necessary for modulation of acquisition, encoding, consolidation, reconsolidation, ...
GABAergic signaling within the basolateral amygdala complex modulates resistance to the labilization/reconsolidation process
(Academic Press Inc Elsevier Science, 2017-10)
It is well known that stress can affect mnemonic processes. In particular, stress before contextual fear conditioning induces a memory which exhibits resistance to being interfered with by Midazolam (MDZ) when applied after ...
Role of prediction error and the cholinergic system on memory reconsolidation processes in mice
(Academic Press Inc Elsevier Science, 2021-11)
The ability to make predictions based on stored information is a general coding strategy. A prediction error (PE) is a mismatch between expected and current events. Our memories, like ourselves, are subject to change. Thus, ...
Scopolamine prevents retrograde memory interference between two different learning tasks
(Pergamon-Elsevier Science Ltd, 2011-03)
Subjects exposed to learning experiences could store the new information through memory consolidation process. If consolidation is interfered by exposing the experimental subjects to another novel stimulus, memory of the ...
Papel de mTOR, BDNF, AMPAR E NMDAR na reconsolidação da memória de extinção
(BrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM PSICOBIOLOGIA, 2019-03-15)
Memory reactivation can induce two apparently competing processes,
namely extinction and reconsolidation. Extinction involves reduction of a
previously acquired response to a stimulus through formation of a new memory
trace. ...
Resistance to fear memory destabilization triggers exaggerated emotional-like responses following memory reactivation
(Pergamon-Elsevier Science Ltd, 2019-07)
Fear memory reactivation does not always lead to memory destabilization-reconsolidation. For instance, fear memories formed following withdrawal from chronic ethanol consumption or a stressful event are less likely to ...