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A unique substitution at position 333 on the glycoprotein of rabies virus street strains isolated from non-hematophagous bats in Brazil
(SPRINGER, 2009)
The amino acid R or K at position 333 on the glycoprotein of the rabies virus is considered necessary for virulence in adult mice. Although some exceptions exist, substitution at this position causes expression of a phenotype ...
Genetic and phylogenetic analysis of glycoprotein of rabies virus isolated from several species in Brazil
(Japan Soc Vet Sci, 2004-07-01)
Genetic and phylogenetic analyses of the region containing the glycoprotein (G) gene, which is related to pathogenicity and antigenicity, and the G-L intergenic region were carried out in 14 Brazilian rabies virus isolates. ...
Genetic and phylogenetic analysis of glycoprotein of rabies virus isolated from several species in Brazil
(Japan Soc Vet Sci, 2004-07-01)
Genetic and phylogenetic analyses of the region containing the glycoprotein (G) gene, which is related to pathogenicity and antigenicity, and the G-L intergenic region were carried out in 14 Brazilian rabies virus isolates. ...
Target cells for antibodies detection in rabies vaccine control
(Elsevier, 2014-03)
Rabies causes one of the most lethal zoonotic diseases, with more than 55,000 deaths reported annually. Prevention is based on pre‑exposure vaccination of individuals at high risk of contracting rabies, and mass vaccination ...
Transient expression of rabies virus G-glycoprotein using BHK-21 cells cultured in suspension
(2015)
Objective To assess the expression of rabies virus G-glycoprotein (RVGP) expression using Semliki Forest virus as a vector in combination with BHK-21 cells cultured in suspension. Results A multilevel factorial design was ...
Purification of rabies virus glycoprotein produced in Drosophila melanogaster S2 cells: An efficient immunoaffinity method
(2020-01-01)
Most rabies vaccines are based on inactivated virus, which production process demands a high level of biosafety structures. In the past decades, recombinant rabies virus glycoprotein (RVGP) produced in several expression ...
DROSOPHILA S2 cell culture in a WAVE Bioreactor: potential for scaling up the production of the recombinant rabies virus glycoprotein
(Springer, 2018-06-01)
The transmembrane rabies virus glycoprotein (RVGP) is the main antigen of vaccine formulations used around the world to prevent rabies, the most lethal preventable infectious disease known. The objective of this work was ...
Highly efficient production of rabies virus glycoprotein G ectodomain in Sf9 insect cells
(Springer, 2019-11)
In the present study, we developed a complete process to produce in insect cells a high amount of the ectodomain of rabies virus glycoprotein G (GE) as suitable antigen for detecting anti-rabies antibodies. Using the ...
Rabies virus-like particles expressed in HEK293 cells
(Elsevier, 2014-03)
Rabies is an infectious viral disease with a mortality rate close to 100%. Currently, there is a need to generate cheaper and more immunogenic vaccines for the effective prevention of rabies, mostly in developing countries. ...