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Electrochemical, ESR and theoretical insights into the free radical generation by 1,1'-hydrocarbylenebisindazoles and its evaluation as potential bio-active compounds
(2012)
A comprehensive multidisciplinary study is conducted here in order to assess the electrochemical behavior of a series of 1,1'-hydrocarbylenebisindazoles derivatives and its potential use as anti-T.cruzi drugs. At first, ...
Microsomal oxidative damage promoted by acetaminophen metabolism
(PERGAMON-ELSEVIER SCIENCE LTD., 2011-10)
Adverse reactions of acetaminophen have been associated to oxidative stress, which may be elicited by
reactive oxygen species (ROS) and/or production of the metabolite NAPQI. Both phenomena would arise
through the activity ...
Redox Cycling of β-Lapachone and Structural Analogues in Microsomal and Cytosol Liver Preparations
(Elsevier Academic Press Inc, 2004-12)
The lipophilic o-naphthoquinones beta-lapachone and structural analogous quinones (CG quinones) are proposed as cytostatic, trypanocidal and antiviral agents. With rat liver microsomal NAD(P)H cytochrome P450 reductase or ...
Hepatic alteration of tryptophan metabolism in an acute porphyria model. Its relation with gluconeogenic blockage
(Pergamon-Elsevier Science Ltd, 2008-02)
This study focuses on the alterations suffered by the serotoninergic and kinurenergic routes of tryptophan (TRP) metabolism in liver, and their relation with gluconeogenic phosphoenolpyruvate-carboxykinase (PEPCK) blockage ...
Actividad antioxidante y efecto ansiolítico de extractos secos estandarizados de Melissa officinalis y Rosmarinus officinalis en ratas Sprague Dawley
(Universidad de Chile, 2015)
Las plantas poseen una gran cantidad de compuestos antioxidantes, tales como polifenoles, los cuales han sido aprovechados ampliamente en la medicina popular a través del consumo de estas plantas medicinales para tratar ...