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Protective action of ppGpp in microcin J25-sensitive strains
(American Society for Microbiology, 2008-06)
As Escherichia coli strains enter the stationary phase of growth they become more resistant to the peptide antibiotic microcin J25. It is known that starvation for nutrients such as amino acids or glucose leads to increases ...
The antimicrobial peptide microcin J25 stabilizes the gel phase of bacterial model membranes
(Elsevier Science, 2015-05)
The bacterial membrane interaction of the antimicrobial peptide microcin J25 was studied with the probe-free techniques Langmuir monolayers and infrared spectroscopy. Membrane model systems composed by phosphatidylethano ...
The leucine-responsive regulatory protein, Lrp, modulates microcin J25 intrinsic resistance in Escherichia coli by regulating expression of the YojI microcin exporter
(American Society for Microbiology, 2009-02)
Many Escherichia coli K-12 strains display an intrinsic resistance to the peptide antibiotic microcin J25. In this study, we present results showing that the leucine-responsive regulatory protein, Lrp, is involved in this ...
Microcin J25 membrane interaction: Selectivity toward gel phase
(Elsevier Science, 2011-06)
The interaction of the tryptophan-containing variant of microcin J25, MccJ25 I13W, with phosphatidylcholine membranes was studied by fluorescence spectroscopy techniques. The peptide was able to interact with dimiristoyl ...
Structural characterization of microcin E492 amyloid formation: Identification of the precursors
(2012)
Microcin E492 is a low-molecular weight, channel-forming bacteriotoxin that generates amyloid structures. Using electron microscopy and image processing techniques several structural conformations can be observed. Prior ...
YojI of Escherichia coli Functions as a Microcin J25 Efflux Pump
(American Society for Microbiology, 2005-05)
In the present study, we showed that yojI, an Escherichia coli open reading frame with an unknown function, mediates resistance to the peptide antibiotic microcin J25 when it is expressed from a multicopy vector. Disruption ...
Cytochromes bd-I and bo3 are essential for the bactericidal effect of microcin J25 on Escherichia coli cells
(Elsevier Science, 2017-10)
Microcin J25 has two targets in sensitive bacteria, the RNA polymerase, and the respiratory chain through inhibition of cellular respiration. In this work, the effect of microcin J25 in E. coli mutants that lack the terminal ...
Molecular characterization of a DNA fragment carrying the basic replicon of pTUC100, the natural plasmid encoding the peptide antibiotic microcin J25 system
(Academic Press Inc Elsevier Science, 2005-12)
The Escherichia coli plasmid pTUC100 encodes production of, and immunity to, the peptide antibiotic microcin J25. In the present study, an approximately 8-kb fragment immediately adjacent to the previously sequenced microcin ...
Potential applicability of chymotrypsin-susceptible microcin J25 derivatives to food preservation
(American Society for Microbiology, 2009-09)
Microcin J25 (MccJ25) is a 21-residue ribosomally synthesized lariat peptide antibiotic. MccJ25 is active against such food-borne disease-causing pathogens as Salmonella spp., Shigella spp., and Escherichia coli, including ...
The Ile13 residue of microcin J25 is essential for recognition by the receptor FhuA, but not by the inner membrane transporter SbmA
(Wiley Blackwell Publishing, Inc, 2009-01)
Entry of the peptide antibiotic microcin J25 (MccJ25) into target cells is mediated by the outer membrane receptor FhuA and the inner membrane protein SbmA. The latter also transports MccB17 into the cell cytoplasm. ...