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Cytotoxic dibromostyrosine-derived metabolites from the sponge Aplysina gerardogreeni
(Bioorganic & Medicinal Chemistry, 2007)
The chemical study of the sponge Aplysina gerardogreeni collected at the Gulf of California has led to the isolation of four new dibromotyrosine-derived metabolites, aplysinones A-D, whose structures were determined by ...
Diuron metabolites and urothelial cytotoxicity: In vivo, in vitro and molecular approaches
(Elsevier B.V., 2013-12-15)
Diuron is carcinogenic to the rat urinary bladder at high dietary levels. The proposed mode of action (MOA) for diuron is urothelial cytotoxicity and necrosis followed by regenerative urothelial hyperplasia. Diuron-induced ...
Comparative effects of fipronil and its metabolites sulfone and desulfinyl on the isolated rat liver mitochondria
(Elsevier B. V., 2015)
Fipronil is an insecticide extensively used to control pests in crops and animals. There are relates of poisoning due to exposure of fipronil in mammals and the liver has been suggested as potential target. In this study, ...
New pioglitazone metabolites and absence of opened-ring metabolites in new n-substituted thiazolidinedione
(2018-06-01)
Thiazolidinediones (TZDs) are drugs used to treat type 2 diabetes mellitus; however, several safety concerns remain regarding the available drugs in this class. Therefore, the search for new TZD candidates is ongoing; ...
Detection of tamoxifen metabolites by GC-MSD
(PRESTON PUBLICATIONS INC, 2004-11)
Tamoxifen is an antiestrogen used in the adjuvant endocrine
therapy of early breast cancer and malignant breast disorders. It is
also used in women with anovulatory infertility caused by its
stimulating effect on the ...
Role of rhizobacterial secondary metabolites in crop protection against agricultural pests and diseases
(Elsevier, 2019)
Bacteria colonizing the rhizosphere of plants (=rhizobacteria) play different ecological roles in their natural environment. Some are deleterious to plant growth and health, while many others are beneficial and act as both ...
Filamentous fungi from extreme environments as a promising source of novel bioactive secondary metabolites
(Frontiers Media S.A., 2015)
Natural product search is undergoing resurgence upon the discovery of a huge previously unknown potential for secondary metabolite (SM) production hidden in microbial genomes. This is also the case for filamentous fungi, ...
Plant Metabolomics Using NMR Spectroscopy
(2019-01-01)
The major goal in plant metabolomics is to study complex extracts for the purposes of metabolic exploration and natural products discovery. To achieve this goal, plant metabolomics relies on accurate and selective acquisition ...
Exogenous influences on plant secondary metabolite levels
(ELSEVIER SCIENCE BVAMSTERDAM, 2012)
Plant secondary metabolites are a group of naturally occurring compound classes biosynthesized by differing biochemical pathways whose plant content and regulation is strongly susceptible to environmental influences and ...