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Construção de híbridos dos interferons humanos beta e alfa2: papel das alfa-helices e alças na atividade biológica
(Universidade Federal de Minas GeraisUFMG, 2005-05-13)
Interferons are proteins involved in the organism defense processes, derived from cellular responses to microorganisms, tumors and antigens and are classified in type I, comprehending the IFN-, IFN-, IFN-, IFN-, IFN- and ...
Endogenous accumulation of IFN-gamma in IFN-gamma-R-/- mice increases resistance to B16F10-Nex2 murine melanoma: a model for direct IFN-gamma anti-tumor cytotoxicity in vitro and in vivo
(Taylor & Francis As, 2002-06-01)
Syngeneic IFN-gamma - / - and IRF-1 - / - mice are very sensitive to B16F10-Nex2 murine melanoma cells implanted subcutaneously. in contrast, IFN-gamma-R - / - (GRKO) mice are remarkably resistant to tumor development. ...
Normal expression of IFN-gR in four patients with uncommon mycobacterial infection phenotypes
(2004)
Several primary immunodeficiency diseases affecting the interleukin 12/interferon gamma (IFN-g) pathway have been identified, most of them characterized by recurrent and protracted infections produced by intracellular ...
IFN-gamma production by CD8+ T cells depends on NFAT1 transcription factor and regulates Th differentiation
(American Association of Immunologists, 2020)
De-immunized and Functional Therapeutic (DeFT) versions of a long lasting recombinant alpha interferon for antiviral therapy
(Academic Press Inc Elsevier Science, 2017-01)
Interferon α (IFN-α) exerts potent antiviral, immunomodulatory, and antiproliferative activity and have proven clinical utility in chronic hepatitis B and C virus infections. However, repeated IFN-α administration induces ...
Compuestos naturales y sintéticos que modulen la actividad biológica de los interferones de tipo I: análisis mediante una nueva herramienta biológica
(2014-05-03)
Los interferones son importantes glicoproteínas del sistema inmunológico, ampliamente utilizados como biofármacos para el tratamiento de diversas patologías. En este trabajo de tesis se desarrolló un ensayo de gen reportero ...
Papel do IFN- e da iNOS na patogênese do dengue experimental
(Universidade Federal de Minas GeraisUFMG, 2009-06-08)
Dengue is currently the most important mosquito-borne disease that affects humans and constitutes a serious world health problem. The lack of specific treatment and vaccine, and the incipient knowledge about pathogenesis ...