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A cure for HIV on the horizon
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The five HIV cures
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Antiretroviral Initiation at >= 800 CD4+Cells/mm(3) Associated With Lower Human Immunodeficiency Virus Reservoir Size
(Oxford University Press, 2022)
Background: Identifying factors that determine the frequency of latently infected CD4+ T cells on antiretroviral therapy (ART) may inform strategies for human immunodeficiency virus (HIV) cure. We investigated the role of ...
A general hazard model for lifetime data in the presence of cure rate
(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2011)
Historically, the cure rate model has been used for modeling time-to-event data within which a significant proportion of patients are assumed to be cured of illnesses, including breast cancer, non-Hodgkin lymphoma, leukemia, ...
Another patient has cured HIV infection
Up to date, a sterilizing cure of HIV-1 infection has been reported in only two persons living with HIV-1 who underwent allogeneic hematopoietic stem cell transplantations from donors who were homozygous for the CCR5 Δ32 ...
Gene editing for HIV cure at the edge
Whereas advances in antiretroviral therapy and its widespread use are providing huge benefits in terms of prventing new HIV transmissions to uninfected individuals as well as halting disease progression in patients, the ...
HIV latency reversal agents: A potential path for functional cure?
(2021-03-05)
Despite the advances in Human Immunodeficiency Virus (HIV) treatment, the cure for all HIV patients still poses a major challenge, which needs to be surpassed in the coming years. Among the strategies pursuing this aim, ...