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Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
(Pergamon-Elsevier Science Ltd, 2004-04)
Meridianins are brominated 3-(2-aminopyrimidine)-indoles which are purified from Aplidium meridianum, an Ascidian from the South Atlantic (South Georgia Islands). We here show that meridianins inhibit various protein kinases ...
The ADP-dependent Sugar Kinase Family: Kinetic and Evolutionary Aspects
(JOHN WILEY & SONS INC, 2009-03-28)
Some archaea of the Euryarchaeota present a unique version
of the Embden–Meyerhof pathway where glucose and fructose-
6-phosphate are phoshporylated using ADP instead of ATP as
the phosphoryl donor. These are the only ...
Targeting to C-terminal myosin heavy chain may explain mechanotransduction involving focal adhesion kinase in cardiac myocytes
(Lippincott Williams & WilkinsPhiladelphiaEUA, 2005)
Src-family kinase inhibitors block early steps of caveolin-1-enhanced lung metastasis by melanoma cells
(Elsevier, 2020)
In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that ...
Src-family kinase inhibitors block early steps of caveolin-1-enhanced lungmetastasis by melanoma cells
(2020)
In advanced stages of cancer disease, caveolin-1 (CAV1) expression increases and correlates with increased migratory and invasive capacity of the respective tumor cells. Previous findings from our laboratory revealed that ...
Specificity evolution of the ADP-dependent sugar kinase family: in silico studies of the glucokinase/phosphofructokinase bifunctional enzyme from Methanocaldococcus jannaschii.
(Federation of European Biochemical Societies, Blackwell Publishing Ltd, 2008-07-10)
In several archaea of the Euryarchaeota, the glycolytic flux proceeds through a modified version of the Embden-Meyerhof pathway, where the phosphofructokinase and glucokinase enzymes use ADP as the phosphoryl donor. These ...
Activation of zebrafish Src family kinases by the prion protein is an amyloid-beta-sensitive signal that prevents the endocytosis and degradation of
(Springer, 2016)
BACKGROUND: Prions and amyloid-beta (Abeta) oligomers trigger neurodegeneration by hijacking a poorly understood cellular signal mediated by the prion protein (PrP) at the plasma membrane. In early zebrafish embryos, ...
AGC kinases, mechanisms of regulation and innovative drug development
(Academic Press Ltd - Elsevier Science Ltd, 2018-02)
The group of AGC kinases consists of 63 evolutionarily related serine/threonine protein kinases comprising PDK1, PKB/Akt, SGK, PKC, PRK/PKN, MSK, RSK, S6K, PKA, PKG, DMPK, MRCK, ROCK, NDR, LATS, CRIK, MAST, GRK, Sgk494, ...